SPATIAL-ORGANIZATION OF THE AUDITORY-NERVE ACCORDING TO SPONTANEOUS DISCHARGE RATE
SPATIAL-ORGANIZATION OF THE AUDITORY-NERVE ACCORDING TO SPONTANEOUS DISCHARGE RATE
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DOI：
10.1002/cne.903190210
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发表时间：
1992-05-08
影响因子：
2.5
通讯作者：
LIBERMAN, MC
中科院分区：
文献类型：
--
作者：
KAWASE, T;LIBERMAN, MC
哺乳动物的听神经纤维按其自发放电率（SR）可分为三类。在猫中，这些SR组的外周末梢围绕感觉细胞圆周分离（Liberman，'82，Science 216：1239-1241）。目前的研究表明，这种空间分离至少部分地通过从感觉细胞到螺旋神经节的外周轴突过程来维持。细胞内标记的前庭神经纤维的分析表明，外周轴突和细胞体的低和中等SR纤维往往被发现更接近前庭阶比高SR纤维。由于低和中等SR纤维往往更薄，这种基于SR的分离也可以被证明为骨螺旋板中的纤维口径梯度。基于SR的空间分离的问题与前庭阶附近的神经节细胞比鼓阶附近的细胞投射到耳蜗核的不同区域的报道有关（泄漏和Snyder，'89，J.Comp.Neurol. 281：612-629）。结合这两项研究的结果表明，耳蜗核的输入可能存在一些基于SR的空间分离。
Auditory-nerve fibers in mammals have been classified into three functional subclasses according to spontaneous discharge rate (SR). In cat, the peripheral terminals of these SR groups are segregated around the sensory cell circumference (Liberman, '82, Science 216:1239-1241). The present study shows that this spatial segregation is at least partly maintained through the peripheral axonal course from sensory cell to spiral ganglion. Analysis of intracellularly labeled auditory-nerve fibers shows that peripheral axons and cell bodies of low-and medium-SR fibers tend to be found closer to scala vestibuli than high-SR fibers. Since low-and medium-SR fibers tend to be thinner, this SR-based segregation can also be demonstrated as a fiber-caliber gradient in the osseous spiral lamina. The issue of SR-based spatial segregation is relevant to reports that ganglion cells near scala vestibuli project to different regions of the cochlear nucleus than cells near scala tympani (Leake and Snyder, '89, J. Comp. Neurol. 281:612-629). Combining the results of the two studies suggests that there may be some SR-based spatial segregation of inputs to the cochlear nucleus.