TGF-β Family Signaling in the Control of Cell Proliferation and Survival
TGF-β Family Signaling in the Control of Cell Proliferation and Survival
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DOI：
10.1101/cshperspect.a022145
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发表时间：
2017-04-01
影响因子：
7.2
通讯作者：
Wang, Xiao-Fan
中科院分区：
文献类型：
--
作者：
Zhang, Yun;Alexander, Peter B.;Wang, Xiao-Fan
转化生长因子 β (TGF-β) 家族控制着细胞行为的许多基本方面。随着 TGF-β 信号级联的分子细节及其与其他信号传导途径的相互作用的进展，我们现在对 TGF-β 诱导的细胞抑制程序有了更一致的理解。然而，对于由 TGF-β 调节并决定细胞增殖和存活、细胞凋亡、休眠、自噬和衰老的其他细胞过程，其分子机制仍然很大程度上难以捉摸。定义 TGF-β 作用的困难部分源于 TGF-β 信号传导的背景依赖性。在这里，我们回顾了目前对 TGF-b 在细胞水平上的生物学效应的理解和最新进展，希望提供一个框架来了解细胞如何在特定情况下响应 TGF-β 信号，以及为什么这种机制的破坏可能导致包括癌症在内的不同人类疾病。
The transforming growth factor beta (TGF-beta) family controls many fundamental aspects of cellular behavior. With advances in the molecular details of the TGF-beta signaling cascade and its cross talk with other signaling pathways, we nowhave a more coherent understanding of the cytostatic program induced by TGF-beta. However, the molecular mechanisms are still largely elusive for other cellular processes that are regulated by TGF-beta and determine a cell's proliferation and survival, apoptosis, dormancy, autophagy, and senescence. The difficulty in defining TGF-beta's roles partly stems from the context-dependent nature of TGF-beta signaling. Here, we review our current understanding and recent progress on the biological effects of TGF-b at the cellular level, with the hope of providing a framework for understanding how cells respond to TGF-beta signals in specific contexts, and why disruption of such mechanisms may result in different human diseases including cancer.