The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
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DOI：
10.1210/jc.2003-031069
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发表时间：
2004-07-01
影响因子：
5.8
通讯作者：
Jones, TH
中科院分区：
文献类型：
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作者：
Malkin, CJ;Pugh, PJ;Jones, TH
睾酮具有免疫调节特性，目前的体外证据表明，睾酮可能抑制促炎细胞因子TNF α、IL-1 β和IL-6的表达，并增强促炎细胞因子IL-10的表达。我们报告了一项随机、单盲、安慰剂对照、交叉研究，在27名有症状的雄激素缺乏症（总睾酮，4.4+/-1.2 nmol/L;生物可利用睾酮，2.4 +/-1.1 nmol/L）男性（年龄62 ± 9岁）中比较睾酮替代（Sustanon 100）与安慰剂。与安慰剂相比，睾酮诱导TNF α减少，（-3.1+/-8.3 vs. 1.3+/-5.2 pg/ml; P=0.01）和IL-1 β（-0.14+/-0.32 vs. 0.18+/-0.55 pg/ml; P=0.08）和IL-10增加（0.33+/-1.8 vs. -1.1+/-3.0 pg/ml; P=0.01）; TNF α和IL-1 β的降低呈正相关（r（S）=0.588; P=0.003）。此外，睾酮治疗组总胆固醇显著降低（-0.25+/-0.4 vs.-0.004+/-0.4 mmol/L; P=0.04）。总之，睾酮替代将细胞因子平衡转移到减少炎症和降低总胆固醇的状态。这些男性中有20人已确诊冠心病，由于总胆固醇是心血管危险因素，促炎细胞因子介导动脉粥样硬化斑块的发展和并发症，这些特性可能与明显的血管疾病男性特别相关。
Testosterone has immune-modulating properties, and current in vitro evidence suggest that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10. We report a randomized, single-blind, placebo-controlled, crossover study of testosterone replacement (Sustanon 100) vs. placebo in 27 men (age, 62+/-9 yr) with symptomatic androgen deficiency (total testosterone, 4.4+/-1.2 nmol/liter; bioavailable testosterone, 2.4+/-1.1 nmol/liter). Compared with placebo, testosterone induced reductions in TNFalpha (-3.1+/-8.3 vs. 1.3+/-5.2 pg/ml; P=0.01) and IL-1beta(-0.14+/-0.32 vs. 0.18+/-0.55 pg/ml; P=0.08) and an increase in IL-10 (0.33+/-1.8 vs. -1.1+/-3.0 pg/ml; P=0.01); the reductions of TNFalpha and IL-1beta were positively correlated (r(S)=0.588; P=0.003). In addition, a significant reduction in total cholesterol was recorded with testosterone therapy (-0.25+/-0.4 vs. -0.004+/-0.4 mmol/liter; P=0.04). In conclusion, testosterone replacement shifts the cytokine balance to a state of reduce inflammation and lowers total cholesterol. Twenty of these men had established coronary disease, and because total cholesterol is a cardiovascular risk factor, and proinflammatory cytokines mediate the development and complications associated with atheromatous plaque, these properties may have particular relevance in men with overt vascular disease.