LUNG ELASTICITY IN REGIONAL AND DIFFUSE PULMONARY FIBROSIS
LUNG ELASTICITY IN REGIONAL AND DIFFUSE PULMONARY FIBROSIS
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DOI：
10.1152/jappl.1979.47.1.138
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
JOHANSON, WG
中科院分区：
文献类型：
--
作者：
FINE, R;MCCULLOUGH, B;JOHANSON, WG
对5只正常[切除]狒狒[Papio cynocephalus]肺，4只放射诱导的上叶纤维化和2只弥漫性博莱霉素诱导的纤维化进行静态放气空气和生理盐水压力-容积（PV）曲线。目视比较曲线并使用半充盈压力（h）。当绘制成观察到的肺活量与经尿道压的百分比时，辐射相关曲线的形状与对照曲线相似。此外，两组之间的h值无显著差异。博来霉素相关曲线发生了显著偏移，h值增加。PV曲线与结缔组织数据相关。弹性蛋白浓度增加，在照射的上叶通过损失相关成分。弹性蛋白通过代偿性生长在受辐射动物的下叶中积累，并且通过过量生产在博莱霉素相关的肺中积累。胶原蛋白也有类似的趋势，但不那么引人注目。如果结缔组织蓄积存在于相对不可充气的肺单位中或作为代偿性肺生长的一部分，则结缔组织蓄积可能不会导致PV曲线发生偏移。
Static deflation air and saline pressure-volume (PV) curves were performed on 5 normal [excised] baboon [Papio cynocephalus] lungs, 4 with radiation-induced upper lobe fibrosis and 2 with diffuse bleomycin-induced fibrosis. Curves were compared visually and using half-inflation pressures (h). When plotted as percent of observed vital capacity vs. transpulmonary pressure, the radiation-associated curves were similar in shape to control curves. Also, h values were not significantly different between the 2 groups. The bleomycin-associated curves were shifted rightward and exhibited increased h values. PV curves were correlated with connective tissue data. Elastin concentration was increased in the irradiated upper lobes through loss of associated constituents. Elastin accumulated in the lower lobes of the irradiated animals through compensatory growth, and, in the bleomycin-associated lungs, through excessive production. Collagen followed a similar but less dramatic trend. Connective tissue accumulation may not lead to rightward shifted PV curves if accumulation is present in relatively noninflatable lung units or as part of compensatory lung growth.