Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues
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DOI：
10.1016/j.bmc.2006.03.047
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Kurihara, Teruo
中科院分区：
文献类型：
--
作者：
Aoyagi, Yutaka;Takahashi, Yoshinao;Kurihara, Teruo
从 Perovskia abrotanoides（唇形科）的甲醇提取物中分离出七种已知的松香二萜类化合物以及 11-O- 和 12-O-乙酰鼠尾草酸。使用 P388 小鼠白血病细胞研究了目前分离的松香烷二萜的天然和半合成类似物的结构和细胞毒活性关系 (SAR)。 (c) 2006 Elsevier Ltd. 保留所有权利。
Seven known abietane diterpenoids and 11-O- and 12-O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SARs) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells. (c) 2006 Elsevier Ltd. All rights reserved.