Gender-specific hemodynamics in prefrontal cortex during a verbal working memory task by near-infrared spectroscopy
Gender-specific hemodynamics in prefrontal cortex during a verbal working memory task by near-infrared spectroscopy
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DOI：
10.1016/j.bbr.2010.01.033
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Gong, Hui
中科院分区：
文献类型：
--
作者：
Li, Ting;Luo, Qingming;Gong, Hui
工作记忆中是否存在性别差异，局限于前额叶皮层（PFC），在一些fMRI研究中一直存在争议。然而，PFC功能的性别差异的假设尚未得到阐述，血流动力学参数之间的比较，旨在测试性别差异是稀缺的。我们利用近红外光谱在26名男性和24名女性健康志愿者的口头N-back任务。同时记录氧合（Delta[oxy-Hb]）、脱氧（Delta[deoxy-Hb]）和总血红蛋白（Delta[tot-Hb]）浓度的变化。Delta[oxy-Hb]和Delta[tot-Hb]具有明显的性别差异，而Delta[deoxy-Hb]则无性别差异。男性表现出轻微的左侧优势双边激活，而女性表现出左激活。男性的激活比女性更广泛和更强。此外，女性需要一个较低的血流动力学供应比男性获得相当的性能，只有女性表现出血流动力学参数和行为性能之间的正相关。研究结果进一步证实了基于血流动力学的功能成像研究中存在性别效应。我们的研究结果表明，女性拥有更有效的血流动力学在PFC在工作记忆和强调的重要性，研究PFC，以进一步科学地了解性别差异。皇冠版权所有（C）2010由爱思唯尔B. V.出版保留所有权利。
The presence or absence of gender differences in working memory, localized in the prefrontal cortex (PFC), has been debated in a few fMRI studies. However, the hypothesis of gender differences in PFC function has not been elaborated, and comparisons among hemodynamic parameters designed to test for gender differences are scarce. We utilized near-infrared spectroscopy during verbal N-back tasks on 26 male and 24 female healthy volunteers. Changes in the concentrations of oxy- (Delta[oxy-Hb]), deoxy(Delta[deoxy-Hb]) and total hemoglobin (Delta[tot-Hb]) were recorded simultaneously. Delta[oxy-Hb] and Delta[tot-Hb] exhibited obvious gender differences, but Delta[deoxy-Hb] did not. Males showed bilateral activation with slight left-side dominance, whereas females showed left activation. The activation in males was more wide-spread and stronger than in females. Furthermore, females required a lower hemodynamic supply than males to obtain comparable performance, and only females exhibited positive correlations between hemodynamic parameters and behavioral performance. The results reinforce the existence of a gender effect in hemodynamic-based functional imaging studies. Our findings suggest that females possess more efficient hemodynamics in the PFC during working memory and emphasize the importance of studying the PFC to further a scientific understanding of gender differences. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.