Does inflammation have a role in migraine?
Does inflammation have a role in migraine?
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DOI：
10.1038/s41582-019-0216-y
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发表时间：
2019-08-01
影响因子：
38.1
通讯作者：
Warfvinge, Karin
中科院分区：
文献类型：
--
作者：
Edvinsson, Lars;Haanes, Kristian Agmund;Warfvinge, Karin
偏头痛是一种流行的疾病，影响世界人口的15.1%。在大多数情况下，偏头痛发作是散发性的;然而，一些个体的发作频率随着时间的推移逐渐增加，并且高达2%的一般人群发展为慢性偏头痛。这种慢性化的潜在机制尚未解决，但假设涉及一定程度的炎症。在这篇文章中，我们回顾了炎症和偏头痛的相关文献，从发作的开始到慢性化。我们认为偏头痛频率的增加导致慢性偏头痛涉及神经源性神经炎症，可能通过激活三叉神经血管系统的神经元和神经胶质细胞中的蛋白激酶增加细胞因子的表达。我们目前的证据从临床前研究支持这一观点，并讨论了偏头痛治疗的影响。
Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.