CtBPs promote mitotic fidelity through their activities in the cell nucleus
CtBPs promote mitotic fidelity through their activities in the cell nucleus
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DOI：
10.1038/onc.2010.507
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发表时间：
2011-03-01
期刊：
影响因子：
8
通讯作者：
Blaydes, J. P.
中科院分区：
文献类型：
--
作者：
Birts, C. N.;Bergman, L. M.;Blaydes, J. P.
CtBP形成NADH敏感的染色质修饰复合物，其将细胞代谢与基因转录联系起来。它们还在细胞质中调节高尔基体分裂;它们的抑制可因此导致G（2）中的高尔基体依赖性检查点。我们最近已经确定了一个新的作用，CtBP在维持有丝分裂的保真度;抑制CtBP的合成，减少极光B与有丝分裂染色质和染色体异常分离的协会。在这里，我们证明，这是CtBPs与转录调节因子和/或染色质修饰酶在细胞核中的相互作用，而不是它们在高尔基体分裂中的作用，这是至关重要的有丝分裂保真度的维护。Oncogene（2011）30，1272-1280; doi：10.1038/onc.2010.507; 2010年11月8日在线发表
CtBPs form NADH-sensitive chromatin-modifying complexes, which link cellular metabolism to gene transcription. They also function in the cytoplasm to regulate Golgi fissioning; their inhibition can consequently cause a Golgi-dependent checkpoint in G(2). We have recently identified a novel role of CtBPs in the maintenance of mitotic fidelity; inhibition of CtBP synthesis resulting in reduced association of aurora B with mitotic chromatin and aberrant segregation of chromosomes. Here, we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity. Oncogene (2011) 30, 1272-1280; doi:10.1038/onc.2010.507; published online 8 November 2010