Outcomes of World Health Organization-defined Severe Respiratory Distress without Shock in Adults in Sub-Saharan Africa.
Outcomes of World Health Organization-defined Severe Respiratory Distress without Shock in Adults in Sub-Saharan Africa.
复制标题
世界卫生组织定义的撒哈拉以南非洲成人无休克严重呼吸窘迫的结果。
DOI：
10.1164/rccm.202304-0684le
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发表时间：
2024
影响因子：
24.7
通讯作者：
SevereRespiratoryDistressinAfrica(SRDA)Investigators
中科院分区：
文献类型：
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作者：
Chang,BickeyH;Adakun,SusanA;Auma,MaryA;Banura,Patrick;Majwala,Albert;Mbonde,AmirA;McQuade,ElizabethRogawski;Ssekitoleko,Richard;Conaway,Mark;Moore,ChristopherC;SevereRespiratoryDistressinAfrica(SRDA)Investigators
方法我们进行了多队列分析，使用了之前收集的16项基于医院的研究的数据，这些研究是从2009年到2019年在撒哈拉以南非洲的6个国家进行的，其中包括一个以前未发表的数据集(乌干达Masaka的Kitovu医院)(表1)(6)。合并数据集中的变量包括：入院年龄、性别、体温、心率、呼吸频率、收缩压、舒张压、血氧饱和度、格拉斯哥昏迷评分(GCS)和HIV血清水平。汇集的数据集不包括所有参与者的感染原因。我们根据世界卫生组织的标准来定义SRD，但排除了心力衰竭。我们排除了14岁以下的患者。我们用10次迭代的链式方程对缺失数据进行多次填充(7)。我们没有将性别、HIV血清状态或死亡率归因于此。我们使用STATA 13.0(STATA)和SAS Version 9.4(SAS Institute)进行所有分析。
MethodsWe conducted a multi-cohort analysis using previously collected deidentified data pooled from 16 hospital-based studies, which were conducted in six countries throughout sub-Saharan Africa from 2009 through 2019, including one previously unpublished dataset (Kitovu Hospital, Masaka, Uganda)(Table 1)(6). Variables in the pooled dataset included: admission age, sex, temperature, heart rate, respiratory rate, systolic blood pressure, diastolic blood pressure, oxygen saturation, Glasgow coma scale (GCS) score, and HIV serostatus. The pooled dataset did not include causes of infection for all participants. We defined SRD according to WHO criteria with the exception of the exclusion of heart failure. We excluded patients younger than 14 years of age. We imputed missing data using multiple imputation with chained equations with 10 iterations (7). We did not impute sex, HIV serostatus, or mortality. We used Stata 13.0 (Stata) and SAS Version 9.4 (SAS Institute) for all analyses.