Early benefits from weight-loss surgery.
Early benefits from weight-loss surgery.
复制标题
减肥手术的早期益处。
DOI：
10.1016/j.jacc.2009.11.081
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发表时间：
2010
影响因子：
24
通讯作者：
Lux,ThomasR
中科院分区：
文献类型：
--
作者：
Taegtmeyer,Heinrich;Leichman,JoshuaG;Reyes,Manuel;Lux,ThomasR
牛津大学小组（1）进行的仔细研究报告了2种非药物干预（饮食或减肥手术）后体重减轻的有益效果。在后者的情况下，我们已经做了类似的观察，除了在更早的时间点（2）。临床重度肥胖（体重指数47 kg/m2）的减肥手术后3个月，内脏脂肪量（但不是皮下脂肪）、葡萄糖稳态和左心室舒张功能已经正常化（2）。更重要的是，血清瘦素水平急剧下降，肌肉脂肪减少，肌肉脂质分配途径中酶的转录水平大幅下降（3）。我们的意见，连同那些骑士等人。(1)表明减肥手术对心脏功能和全身代谢的影响是由心脏或中枢调节的。
The carefully conducted study by the Oxford group (1) reports beneficial effects of weight loss after 2 nonpharmacological interventions, diet or bariatric surgery. In case of the latter, we have made similar observations except at a much earlier time point (2). Three months after bariatric surgery for clinically severe obesity (body mass index 47 kg/m2), visceral fat mass (but not subcutaneous fat), glucose homeostasis, and left ventricular diastolic function had already normalized (2). More importantly, there was a dramatic decline in serum leptin levels, a decrease in muscle fat, and a massive decrease in transcript levels of enzymes in the pathway of muscle lipid partitioning (3). Our observations, together with those of Rider et al.(1), suggest that the effects of weight-loss surgery on cardiac function and systemic metabolism are either hormonally or centrally regulated.
影响因子：
24
作者：
Rider, Oliver J.;Francis, Jane M.;Neubauer, Stefan
通讯作者：
Neubauer, Stefan