Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
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DOI：
10.1023/a:1011513223894
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发表时间：
2001-01-01
期刊：
影响因子：
4.5
通讯作者：
Kassem, M
中科院分区：
文献类型：
--
作者：
Justesen, J;Stenderup, K;Kassem, M
人体骨骼老化的特点是骨形成和骨量减少，这些变化在骨质疏松症患者中更为明显。由于成骨细胞和脂肪细胞在骨髓中共享一个共同的前体细胞，我们假设在衰老过程中和骨质疏松症患者中观察到的骨形成减少是由于骨髓中前体细胞的脂肪生成与成骨细胞生成增强的结果。因此，我们检查了从 53 名健康正常个体（年龄 30-100 岁）和 26 名骨质疏松症患者（年龄 52-92 岁）获得的髂嵴骨活检。使用点计数法将脂肪组织体积分数（AV）、造血组织体积分数（HV）和小梁骨体积分数（BV）定量为总组织体积分数（TV）的百分比（计算为BV + AV + HV）。我们发现 AV/TV 与年龄相关的增加（r = 0.53，P < 0.001，n = 53），BV/TV 与年龄相关的下降（r = -0.46，P < 0.001，n = 53）以及 HV/TV（r = -0.318，P < 0.05，n = 53）。 BV/TV 和 AV/TV 之间存在与年龄相关的负相关（r = -0.58，P < 0.001）。 AV/TV 和体重指数（r = 0.06，n.s.，n = 52）之间未检测到显着相关性。与年龄匹配的对照组相比，骨质疏松症患者AV/TV升高（P < 0.05），BV/TV降低（P < 0.05），但HV/TV无统计学差异。我们的数据支持这样的假设：随着衰老和骨质疏松症，在骨髓中观察到脂肪生成增强，并且这些机会与骨小梁体积减少呈负相关。介导这些变化的细胞和分子机制仍有待确定。
Aging of the human skeleton is characterized by decreased bone formation and bone mass and these changes are more pronounced in patients with osteoporosis. As osteoblasts and adipocytes share a common precursor cell in the bone marrow, we hypothesized that decreased bone formation observed during aging and in patients with osteoporosis is the result of enhanced adipognesis versus osteoblastogenesis from precursor cells in the bone mar-row. Thus, we examined iliac crest bone biopsies obtained from 53 healthy normal individuals (age 30-100) and 26 patients with osteoporosis (age 52-92). Adipose tissue volume fraction (AV), hematopoietic tissue volume fraction (HV) and trabecular bone volume fraction (BV) were quantitated as a percentage of total tissue volume fraction (TV) (calculated as BV + AV + HV) using the point-counting method. We found an age-related increase in AV/TV (r = 0.53, P < 0.001, n = 53) and an age-related decline in BV/TV (r = -0.46, P < 0.001, n = 53) as well as in the HV/TV (r = -0.318, P < 0.05, n = 53). There was an age-related inverse correlation between BV/TV and AV/TV (r = -0.58, P < 0.001). No significant correlation between the AV/TV and the body mass index (r = 0.06, n.s., n = 52) was detectable. Compared with age-matched controls, patients with osteoporosis exhibited an increased AV/TV (P < 0.05) and decreased BV/TV (P < 0.05) but no statistically significant difference in HV/TV. Our data support the hypothesis that with aging and in osteoporosis an enhanced adipogenesis is observed in the bone marrow and that these chances are inversely correlated to decreased trabecular bone volume. The cellular and molecular mechanisms mediating these changes remain to be determined.