A polymer optoelectronic interface restores light sensitivity in blind rat retinas.
A polymer optoelectronic interface restores light sensitivity in blind rat retinas.
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DOI：
10.1038/nphoton.2013.34
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发表时间：
2013-05
期刊：
影响因子：
35
通讯作者：
Benfenati F
中科院分区：
文献类型：
--
作者：
Ghezzi D;Antognazza MR;Maccarone R;Bellani S;Lanzarini E;Martino N;Mete M;Pertile G;Bisti S;Lanzani G;Benfenati F
由于有机导电聚合物所表现出的有益特性，将有机电子学与生物衬底结合为生物技术提供了新的可能性。这些聚合物已经以多种方式用于细胞界面，包括细胞支架、神经探针、生物传感器和药物释放驱动器。最近，一种有机光伏共混物被用于通过光激发过程刺激神经元。在这里，我们记录了使用聚（3-己基噻吩）（P3HT）的单组分有机薄膜来触发光照下的神经元放电。此外，我们证明了这种生物有机界面可以恢复大鼠视网膜光感受器变性的外植体的光敏性。这些发现表明，全有机装置可能在视网膜下假体植入物中发挥重要作用。
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology due to the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several fashions, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been exploited for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in sub-retinal prosthetic implants.