Possible role of 6‐hydroxymethylbenzo[a]pyrene as a proximate carcinogen of benzo[a]pyrene and 6‐methylbenzo[a]pyrene
Possible role of 6‐hydroxymethylbenzo[a]pyrene as a proximate carcinogen of benzo[a]pyrene and 6‐methylbenzo[a]pyrene
复制标题
6-羟甲基苯并[a]芘作为苯并[a]芘和6-甲基苯并[a]芘的近似致癌物的可能作用
DOI：
10.1002/ijc.2910110221
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发表时间：
1973
影响因子：
6.4
通讯作者：
K. Sydnor
中科院分区：
文献类型：
--
作者：
J. W. Flesher;K. Sydnor
苯并[a]芘 (B[a]P) 和 6-甲基苯并[a]芘 (6-MeB[a]P) 通过强化大鼠肝匀浆代谢为多种代谢物，其中一种通过薄层色谱或紫外吸收光谱无法与 6-羟甲基苯并[a]芘 (6-OHMeB[a]P) 区分。当通过皮下注射给大鼠施用时，该化合物是一种强效致癌物。这些观察结果符合甲基化或羟甲基化是致癌多环烃代谢活化的第一步之一的假设。
Benzo[a]pyrene (B[a]P) and 6‐methylbenzo[a]pyrene ( 6‐MeB[a]P) are metabolized by fortified rat‐liver homogenates to a number of metabolites including one which is indistinguishable from 6‐hydroxymethylbenzo[a]pyrene (6–OHMeB[a]P) by either thin‐layer chromatography or ultra‐violet absorption spectra. This compound is a potent carcinogen when administered by subcutaneous injection to rats. These observations are in accord with the hypothesis that methylation or hydroxymethylation is one of the first steps in metabolic activation of carcinogenic polycyclic hydrocarbons.