ESTIMATED HEAT CONTRIBUTION OF BROWN FAT IN AROUSING GROUND SQUIRRELS (CITELLUS LATERALIS)
ESTIMATED HEAT CONTRIBUTION OF BROWN FAT IN AROUSING GROUND SQUIRRELS (CITELLUS LATERALIS)
复制标题
DOI：
10.1152/ajplegacy.1968.214.1.115
复制
发表时间：
1968-01-01
影响因子：
--
通讯作者：
PENGELLEY, ET
中科院分区：
文献类型：
--
作者：
HORWITZ, BA;SMITH, RE;PENGELLEY, ET
为了评估棕色脂肪相对于完整的地松鼠在从冬眠中唤醒期间的热贡献，推导出体内组织耗氧量的2个近似值作为唤醒时间的函数。通过假设体外代谢反映了体内代谢，从记录的棕色脂肪“升温”曲线获得一个估计值的方程，并且棕色脂肪温度在大部分唤醒期间随QO 2 [耗氧量]线性增加。棕色脂肪产热也近似为在给定时间间隔内观察到的组织温度变化所需的卡路里加上损失到血液中的热量的总和。将计算的组织O2消耗量与测量的总消耗量进行比较，估计棕色脂肪的贡献范围从最初的6-15%到5-8%，因为松鼠接近正常体温。考虑到这些推导中涉及的假设，得出的结论是，计算出的总能量成本的7-11%的平均值代表了在低环境温度下支持唤醒的棕色脂肪产热的最小估计值。
To evaluate the thermal contribution of brown fat relative to that of the intact ground squirrel during arousal from hibernation, 2 approximations of the tissue oxygen consumption in vivo were derived as a function of arousal time. Equations for one estimate were obtained from the recorded brown fat "warming" curves by assuming the metabolism in vitro reflects that in vivo and the brown fat temperature increases linearly with the QO2 [oxygen consumption quotient] druing most of the arousal period. Brown fat thermogenesis was also approximated as the sum of the calories needed for the tissue temperature change observed over a given time interval plus heat lost to the blood. Comparing the calculated tissue O2 consumption with the measured total, the estimated brown fat contribution ranged from 6-15% initially to 5-8% as the squirrels approached normothermic temperatures. In view of the assumptions involved in these derivations, it was concluded that the calculated average of 7-11% of the total energy cost represents minimum estimates of brown fat thermogenesis in support of arousal at low ambient temperatures.