The mediation effect of maternal glucose on the association between ambient air pollution and birth weight in Foshan, China.
The mediation effect of maternal glucose on the association between ambient air pollution and birth weight in Foshan, China.
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DOI：
10.1016/j.envpol.2020.115128
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发表时间：
2020-07
影响因子：
8.9
通讯作者：
Yin Yang;Qingmei Lin;Ying Liang;Zengliang Ruan;Z. Qian;Kevin M Syberg;Steven W. Howard;Changke Wang;B. Acharya;Qi‐hao Zhang;Haibo Ge;Xueli Wu;Kaihua Li;Xiaoling Guo;Hualiang Lin
中科院分区：
文献类型：
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作者：
Yin Yang;Qingmei Lin;Ying Liang;Zengliang Ruan;Z. Qian;Kevin M Syberg;Steven W. Howard;Changke Wang;B. Acharya;Qi‐hao Zhang;Haibo Ge;Xueli Wu;Kaihua Li;Xiaoling Guo;Hualiang Lin
母体血糖水平与胎儿生长发育有关，因此，其在空气污染与出生体重之间的关系中的作用值得研究。我们研究了母亲血糖对母亲空气污染暴露和出生体重之间关系的中介作用。在2015-2019年期间，共招募了10，904名中国佛山的孕妇。口服葡萄糖耐量试验（OGTT）后，每一个参与者晚三个月2。在住宅区的监测站的空气污染数据被用来估计每个参与者在第一个三月和第二个三月的暴露。混合效应线性模型被用来估计空气污染和出生体重之间的关联。在控制了10个协变量后，PM2.5和SO2（每增加10 μg/m3）对出生体重的直接影响在第1个三月分别为-15.7 g（95%CI：-29.4，-4.8 g）和-83.6 g（95%CI：-134.8，-33.0 g）。PM2.5和SO2（每增加10 μg/m3）通过增加孕妇空腹血糖水平对出生体重的间接影响分别为6.6 g（95% CI：4.6，9.1 g）和22.0 g（95% CI：4.1，44.0 g）。研究结果提示，大气污染可能通过直接和间接途径影响新生儿出生体重，其中母体血糖可能介导了大气污染对新生儿出生体重的影响。
Maternal blood glucose level is associated with fetal growth, therefore, its role in the associations between air pollution and birth weight deserves investigation. We examined the mediation effect of maternal blood glucose on the associations between maternal air pollution exposure and birth weight. A total of 10,904 pregnant women in Foshan, China during 2015–2019 were recruited. Oral glucose tolerance test (OGTT) was administered to each participant after late trimester 2. Air pollution data at the monitoring stations in residential districts was used to estimate exposures of each participant during trimester 1 and trimester 2. Mixed-effects linear models were used to estimate the associations between air pollution and birth weight. After controlling for ten covariates, the direct effect of PM2.5and SO2(each 10 μg/m3increment) on birth weight was −15.7 g (95% CI: −29.4, −4.8 g) and −83.6 g (95% CI: −134.8, −33.0 g) during trimester 1. The indirect effect of PM2.5and SO2(each 10 μg/m3increment) on birth weight by increasing maternal fasting glucose level was 6.6 g (95% CI: 4.6, 9.1 g) and 22.0 g (95% CI: 4.1, 44.0 g) during trimester 1. Our findings suggest that air pollution might affect the birth weight through direct and indirect pathway, and the indirect effect might be mediated by maternal blood glucose.