Racial Variations in the Incidence of Severe Alcohol Withdrawal
Racial Variations in the Incidence of Severe Alcohol Withdrawal
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DOI：
10.1007/bf03160974
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Nelson, Lewis S.
中科院分区：
文献类型：
--
作者：
Chan, Gar Ming;Hoffman, Robert S.;Nelson, Lewis S.
使用种族作为风险评估工具和药理学目标最近引起了关注和争论。目前尚不清楚种族与严重酒精戒断的发生之间是否存在关系。我们使用多个研究组探讨了这种潜在关系。方法：同时对患者进行前瞻性入组，并在两个不同的环境中对严重酒精戒断进行回顾性图表审查，比较基于种族的戒断和酗酒发生率。然后将这两个研究组与“有风险”的酗酒者群体和一般 ED 人群进行比较，以确定种族分布的差异。结果：与非白人“有风险”的酗酒者相比，两个研究组中的白人种族个体出现严重酒精戒断的几率 [OR 1.93 (CI 1.11-3.39) 和 2.19 (CI 1.41-3.40)] 增加。然而，与非黑人“有风险”的酗酒者相比，两个研究组中的黑人出现严重酒精戒断的几率似乎较低 [OR 0.23 (CI 0.11-0.47) 和 0.11 (CI 0.05-0.23)]。 结论：尽管在医学研究和靶向治疗中使用种族存在争议，但不同种族的严重酒精戒断几率似乎存在差异。目前尚不清楚这一发现的原因。
The use of race as a risk assessment tool and pharmacologic target has garnered recent attention and debate. It is currently unclear if a relationship between race and the development of severe alcohol withdrawal exists. We explored this potential relationship using several study groups.Methods: A simultaneous prospective enrollment of patients and retrospective chart review of severe alcohol withdrawal in two separate settings was performed comparing both the incidence of withdrawal and alcoholism based on race. These two study groups were then compared to an "at risk" group of alcoholics and the general ED population to determine differences in the distribution of race.Results: Individuals of white race in both study groups were at increased odds [OR 1.93 (CI 1.11-3.39) and 2.19 (CI 1.41-3.40)] of having severe alcohol withdrawal when compared to non-White "at risk" alcoholics. Blacks in both study groups however, appear to have lower odds [OR 0.23 (CI 0.11-0.47) and 0.11 (CI 0.05-0.23)] of having severe alcohol withdrawal when compared to non-Black "at risk" alcoholics.Conclusions: Despite the controversial use of race in medical research and targeting therapies, there appears to be a difference in the odds of severe alcohol withdrawal based on race. The reasons for this finding are currently unclear.