A Uniform Sub-50 nm-Sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet Oxygen by Using a 980 nm Laser
A Uniform Sub-50 nm-Sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet Oxygen by Using a 980 nm Laser
复制标题
能够使用 980 nm 激光产生单线态氧的均匀亚 50 nm 磁性/上转换荧光双峰成像剂
DOI：
10.1002/chem.201103611
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发表时间：
2012-06-01
影响因子：
4.3
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Chen, Feng;Zhang, Shengjian;Shi, Jianlin
上转换纳米粒子（UCNPs）具有独特的性质，在解决传统光动力疗法（PDT）所面临的问题方面具有巨大的潜力。本论文采用精心筛选的双功能钆掺杂UCNP和水溶性亚甲蓝（MB），结合水包油反相微乳液技术，成功制备了一种粒径小于50 nm的UCNP/MB PDT药物NaYF 4：Er/Yb/Gd@SiO2（MB）。人们已经做出了很大的努力来研究药物的形成机制，并提供详细的物理和光化学表征以及设计的PDT药物的潜在结构优化。我们设想，这样的PDT药物将成为一个潜在的治疗诊断纳米医学未来近红外激光触发的光动力治疗和同时磁/光双峰成像。
Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well-selected bifunctional gadolinium (Gd)-ion-doped UCNPs and water-soluble methylene blue (MB) combined with the water-in-oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB-based PDT drug, NaYF4:Er/Yb/Gd@SiO2(MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug-formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as-designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near-infrared laser-triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging.