PROGNOSTIC FACTORS IN WEGENERS GRANULOMATOSIS
PROGNOSTIC FACTORS IN WEGENERS GRANULOMATOSIS
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DOI：
10.1136/pgmj.69.817.856
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发表时间：
1993-11-01
影响因子：
5.1
通讯作者：
NATUSCH, R
中科院分区：
文献类型：
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作者：
BRIEDIGKEIT, L;KETTRITZ, R;NATUSCH, R
我们分析了韦格纳肉芽肿患者的数据，以确定预后的预测变量。确诊后的平均观察期为3.2(0.1-11.2)年。确诊时，15名患者(23%)仅有局部症状。在49例(77%)患者中，该病泛发于多个器官。33例患者进行了肾活检；13例(39%)有毛细血管外肾小球肾炎，这是最常见的肾脏损害。除3名患者外，其余患者均接受了免疫抑制治疗。随访时，17例(27%)患者完全缓解，26例(40%)患者部分缓解。我们使用Kaplan Meier分析来确定结果的预测变量。肾脏受累、初始肌酐浓度、血清白蛋白或总蛋白浓度、白细胞计数和红细胞尿被证明是预测变量。这些变量可能对指导韦格纳肉芽肿患者的治疗强度有价值。
We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1 - 11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multiple organs in 49 (77%) patients. Renal biopsies were obtained in 33 patients; 13 (39%) had extracapillary glomerulonephritis, which was the most common renal lesion. All but three patients received immunosuppressive therapy. At time of follow-up, 17 (27%) patients were in complete, and 26 (40%) in partial remission. We employed a Kaplan Meier analysis to identify predictor variables of outcome. Renal involvement, initial creatinine concentration, serum albumin or total protein concentration, leukocyte count and erythrocyturia proved to be predictor variables. These variables may be of value in guiding the intensity of treatment in patients with Wegener's granulomatosis.