INSULIN INCREASES SYMPATHETIC ACTIVITY BUT NOT BLOOD-PRESSURE IN BORDERLINE HYPERTENSIVE HUMANS
INSULIN INCREASES SYMPATHETIC ACTIVITY BUT NOT BLOOD-PRESSURE IN BORDERLINE HYPERTENSIVE HUMANS
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DOI：
10.1161/01.hyp.19.6.621
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发表时间：
1992-06-01
期刊：
影响因子：
8.3
通讯作者：
MARK, AL
中科院分区：
文献类型：
--
作者：
ANDERSON, EA;BALON, TW;MARK, AL
我们之前已经证明，在血压正常的人中，生理性高胰岛素血症会增加交感神经活性，但不会增加动脉压，因为它也会导致骨骼肌血管扩张。然而，在存在胰岛素抵抗和/或高血压的情况下，胰岛素可能会导致交感神经过度兴奋或血管扩张受损，从而导致动脉血压升高。这项研究试图确定胰岛素是否通过导致交感神经流出的夸大增加或血管扩张受损而导致临界性高血压患者的升压反应。我们记录了13名临界性高血压患者在血糖保持不变的情况下1小时胰岛素输注(38微单位/平方米/分钟)期间的肌交感神经活动(显微神经学检查，腓神经)、前臂血方式、心率和血压。血浆胰岛素由对照组的12+/-3微单位/毫升(均值+/-扫描电子显微镜)升至73+/-7微单位/毫升，停药2小时后降至9+/-2微单位/毫升。对照组的肌交感神经活动平均为25+/-2次/分钟，在胰岛素注射期间显著增加(+9次/分钟)，并在恢复后1.5小时保持较高水平(+7次/分钟，p
We have previously demonstrated that physiological hyperinsulinemia in normotensive humans increases sympathetic nerve activity but not arterial pressure since it also causes skeletal muscle vasodilation. However, in the presence of insulin resistance and/or hypertension, insulin may cause exaggerated sympathetic activation or impaired vasodilation and thus elevate arterial pressure. This study sought to determine if insulin causes a pressor response in borderline hypertensive humans by producing exaggerated increases in sympathetic neural outflow or impaired vasodilation. We recorded muscle sympathetic nerve activity (microneurography, peroneal nerve), forearm blood How, heart rate, and blood pressure in 13 borderline hypertensive subjects during a 1-hour insulin infusion (38 microunits/m2/min) while holding blood glucose constant. Plasma insulin rose from 12+/-3 microunits/ml (mean+/-SEM) during control to 73+/-7 microunits/ml during insulin infusion and fell to 9+/-2 microunits/ml 2 hours after insulin infusion was stopped. Muscle sympathetic nerve activity, which averaged 25+/-2 bursts per minute in control, increased significantly during insulin infusion (+9 bursts per minute) and remained elevated 1.5 hours into recovery (+7 bursts per minute, p