Comparison between sevoflurane and isoflurane anesthesia in pig hepatic ischemia-reperfusion injury.
Comparison between sevoflurane and isoflurane anesthesia in pig hepatic ischemia-reperfusion injury.
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DOI：
10.1007/s540-002-8093-x
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发表时间：
2002-01-01
影响因子：
2.8
通讯作者：
Kanmura, Yuichi
中科院分区：
文献类型：
--
作者：
Ishida, Hiroshi;Kadota, Yoshitami;Kanmura, Yuichi
目的：据报道，七氟烷和异氟烷对多种器官的缺血再灌注损伤（IRI）具有保护作用。为了比较七氟烷麻醉与异氟烷麻醉对肝脏 IRI 的影响，我们在猪身上进行了本研究。方法：将 19 头猪分配到七氟烷组 (n = 9) 或异氟烷组 (n = 10)。吸入麻醉开始后90分钟开始夹闭肝动脉和门静脉30分钟，产生肝脏热缺血；随后进行 240 分钟的再灌注。为了扩展我们的评估，除了常规使用的肝损伤标记物之外，我们还使用各种参数（血浆α-谷胱甘肽-S-转移酶[α-GST]、脂质过氧化物和乳酸浓度）评估IRI的程度。 结果：再灌注后120分钟，异氟醚下的乳酸水平显着高于七氟醚下（4.0+/-0.4） mmol.l(-1) vs 2.5 +/- 0.3 mmol.l(-1)； P<0.05）。然而，再灌注 240 分钟后，这种差异就消失了。两组之间的 α-GST、脂质过氧化物、天冬氨酸转氨酶、丙氨酸转氨酶或乳酸脱氢酶的值没有观察到显着差异。结论：根据对猪七氟烷麻醉下的许多参数的测量判断，猪在七氟烷麻醉下观察到的肝脏 IRI 程度与异氟烷下观察到的肝脏 IRI 程度没有显着差异。 240分钟的再灌注期。
PURPOSE: Sevoflurane and isoflurane have been reported to exert protective effects against ischemia-reperfusion injury (IRI) in various organs. To compare the effect of sevoflurane anesthesia on liver IRI with that of isoflurane anesthesia, we performed the present study in pigs.METHODS: Nineteen pigs were assigned to either the sevoflurane ( n = 9) or the isoflurane group ( n = 10). Hepatic warm ischemia was produced by 30-min hepatic artery and portal vein clamping beginning 90 min after the start of the inhalation anesthesia; this was followed by a 240-min reperfusion. To extend our evaluation, we evaluated the degree of IRI using various parameters (plasma alpha-glutathione-S-transferase [alpha-GST], lipid peroxide, and lactate concentrations), in addition to the conventionally used liver damage markers.RESULTS: The lactate level was significantly higher under isoflurane than under sevoflurane at 120 min after reperfusion (4.0 +/- 0.4 mmol.l(-1) vs 2.5 +/- 0.3 mmol.l(-1); P < 0.05). How-ever, this difference had disappeared after 240 min of reperfusion. No significant differences between the two groups were observed in values for alpha-GST, lipid peroxides, aspartate aminotransferase, alanine aminotransferase, or lactic dehydrogenase.CONCLUSION: The extent of the hepatic IRI seen under sevoflurane anesthesia in pigs did not differ significantly from that seen under isoflurane, as judged from measurements of a number of parameters over a 240-min reperfusion period.