Intervertebral disc lesions: visualisation with ultra-high field MRI at 11.7 T
Intervertebral disc lesions: visualisation with ultra-high field MRI at 11.7 T
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DOI：
10.1007/s00586-015-4146-0
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发表时间：
2015-11-01
影响因子：
2.8
通讯作者：
Wilke, Hans-Joachim
中科院分区：
文献类型：
--
作者：
Berger-Roscher, Nikolaus;Galbusera, Fabio;Wilke, Hans-Joachim
椎间盘的撕裂和裂缝可能影响脊柱的稳定性。以裂缝检测为目的的椎间盘造影研究受到了批评和劝阻。因此，必须研究替代成像方法，如MRI。采用特制装置，将6根不同直径（0.3 ~ 2.2 mm/30 ~ 14 G）的针插入6个牛尾盘（cy2 ~ cy3）的环内。取出针头后，直接在11.7 T MRI （Res. 0.059 x 0.059 x 0.625 mm(3)，扫描时间：31分钟）中扫描椎间盘，在临床和另外两种实验方案的3 T MRI (exp_HR: Res. 0.3 mm（3)， T（扫描）：97分钟/exp_LR: Res. 0.5 mm(3)，扫描时间：13.4分钟）中扫描椎间盘。使用3d重建软件分析获得的图像的病变体积和病变长度。在11.7 T时，所有病变均可见，并伴有环的板层状结构。在临床3t图像中，未见任何病变。3t实验方案显示6个病变中的4个（exp_HR）和2个（exp_LR）。重建的病灶没有形成理想的圆柱形。测量的病灶体积范围为0.7 ~ 13.9 mm(3) （11.7 T）、0.1 ~ 11.4 mm(3) （exp_HR）和0.0 ~ 12.4 mm(3) (exp_LR)，且相关，但均小于相应的针径。所有针损长度为2.9 ~ 12.3 mm (11.7 T), 0.8 ~ 9.7 mm （exp_HR）和0.0 ~ 9.7 mm （exp_LR）。11.7 T的超高场MRI是一种非侵入性工具，可以直接观察体外环形病变，而3t MRI，即使采用实验方案和更长的扫描时间，也显示出有限的能力。在体内，目前可用的临床系统存在问题。
Tears and fissures in the intervertebral disc are probably influencing spinal stability. Discography investigations with the aim of fissure detection have been criticised and are discouraged. Therefore, alternative imaging methods, such as MRI, must be investigated.A custom-made device was used to insert six needles with different diameters (0.3-2.2 mm/30-14 G) into the annulus of six bovine tail discs (Cy2-Cy3). Directly after removal of the needles, the discs were scanned in an 11.7 T MRI (Res.: 0.059 x 0.059 x 0.625 mm(3), tscan: 31 min), in a 3 T MRI with a clinical and additionally with two experimental protocols (exp_HR: Res.: 0.3 mm(3), t(scan): 97 min/exp_LR: Res.: 0.5 mm(3), tscan: 13.4 min). The obtained images were analysed for lesion volume and lesion length using a 3D-reconstruction software.At 11.7 T, all lesions were visible along with the lamellar structure of the annulus. In the clinical 3 T images, no lesions were visible at all. The 3 T experimental protocols revealed 4 (exp_HR) and 2 (exp_LR) of the 6 lesions. The reconstructed lesions did not have an ideal cylindrical shape. The measured volumes of the lesions ranged from 0.7 to 13.9 mm(3) (11.7 T), 0.1-11.4 mm(3) (exp_HR) and 0.0-12.4 mm(3) (exp_LR) and correlated, but were smaller than the corresponding needle size. The lengths of all needle lesions ranged from 2.9 to 12.3 mm (11.7 T), 0.8-9.7 mm (exp_HR) and 0.0-9.7 mm (exp_LR).Ultra-high field MRI at 11.7 T is a non-invasive tool to directly visualise annular lesions in vitro, while a 3 T MRI, even with experimental protocols and longer scanning times, demonstrates limited ability. In vivo, it is problematic with the clinical systems available today.