Respiratory Morbidity and Lung Function Analysis During the First 36 Months of Life in Infants With Bronchopulmonary Dysplasia (BPD)
Respiratory Morbidity and Lung Function Analysis During the First 36 Months of Life in Infants With Bronchopulmonary Dysplasia (BPD)
复制标题
支气管肺发育不良 (BPD) 婴儿出生后 36 个月内的呼吸系统发病率和肺功能分析
DOI：
10.3389/fped.2019.00540
复制
发表时间：
2020-01-10
影响因子：
2.6
通讯作者：
Zhu, Xiaoli
中科院分区：
文献类型：
--
作者：
Chen, Dandan;Chen, Jing;Zhu, Xiaoli
目的：探讨早产儿支气管肺发育不良（BPD）的肺功能，指导临床预防、早期诊断和治疗。方法：选取4 ~ 36月龄BPD患儿30例，分为轻度BPD组和中重度BPD组。30名足月健康婴儿和30名4-36个月矫正胎龄的非bpd婴儿作为对照。比较两组患者的临床信息，包括呼吸道感染和再次住院。此外，对婴儿进行肺功能分析。结果：BPD患儿上呼吸道感染率及再住院率明显高于非BPD患儿。BPD组的潮气量/kg、到达潮气量峰值时间/总呼气时间、潮气量峰值/总潮气量均显著低于非BPD组。随着BPD严重程度的增加，这些值逐渐降低。BPD组呼吸频率（RR）明显高于非BPD组。随着BPD严重程度的增加，潮汐呼吸流量环（TBFVL）到期下降支斜率增大。结论：BPD严重程度与呼吸系统预后不良有关。TBFVL可直接反映不同程度BPD患儿潮汐肺功能的特点。
Purpose: To explore the lung function of bronchopulmonary dysplasia (BPD) in premature infants to guide clinical prevention, early diagnosis and treatment. Methods: Thirty infants with BPD at 4-36 months of corrected gestational age were enrolled and divided into mild BPD and moderate and severe BPD groups. Thirty full-term healthy infants, and 30 non-BPD infants at 4-36 months of corrected gestational age were included as controls. Clinical information, including respiratory infections and re-hospitalization, was compared among these groups. Furthermore, lung function analysis was performed in the infants. Results: The upper respiratory tract infection rate and re-hospitalization rate were significantly higher in the infants with BPD than in the non-BPD infants. The tidal volume/kg, proportion of time to reach peak tidal expiratory flow/total expiratory time, tidal volume exhaled at peak tidal expiratory flow/total tidal volume in BPD group were significantly lower in the BPD group than those in non-BPD group. These values gradually decreased as the severity of BPD increased. The respiratory rate (RR) in BPD group was significantly higher than that in non-BPD group. As the severity of the BPD increased, slope of the descending branch of expiration of tidal breathing flow capacity ring (TBFVL) increased. Conclusion: There is a correlation between the severity of BPD and a poor prognosis of respiratory system. TBFVL can directly reflect the characteristics of Tidal Pulmonary Function in children with different degrees of BPD.