Antimicrobial susceptibility profiles of Helicobacter pylori isolated from patients in North India
Antimicrobial susceptibility profiles of Helicobacter pylori isolated from patients in North India
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DOI：
10.1016/j.jgar.2015.09.009
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发表时间：
2016-06-01
影响因子：
4.6
通讯作者：
Das, Rajashree
中科院分区：
文献类型：
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作者：
Gehlot, Valentina;Mahant, Shweta;Das, Rajashree
幽门螺杆菌相关的胃十二指肠疾病在印度非常常见。对常用抗生素的耐药性。幽门螺杆菌的数量正在迅速增加。本研究的目的是确定H. pylori菌株对抗常用的抗生素。幽门螺杆菌治疗幽门螺杆菌培养68例患者患有各种胃十二指肠疾病在印度北部。采用琼脂稀释法测定不同抗生素的最低抑菌浓度（MIC）。68例H. pylori培养阳性的有胃食管反流病（GERD）23例，非糜烂性反流病（NERD）22例，非溃疡性消化不良（NUD）13例，胃窦炎3例，十二指肠溃疡2例，其他5例。在68 H。pylori分离株中，20株（29.4%）无耐药。耐药率为70.6%，其中耐甲硝唑48.5%，耐呋喃唑酮22.1%，耐阿莫西林17.6%，耐四环素16.2%，耐克拉霉素11.8%。分别有26.5%和8.8%的病例出现双重和多重耐药。总之，超过三分之二的分离的H。pylori菌株对至少一种H.幽门螺杆菌治疗甲硝唑耐药是最普遍的测试之间的分离。双重和多重耐药性的出现令人极为关切，迫切需要定期进行抗生素耐药性监测研究。阿莫西林和克拉霉素为基础的抗H。pylori方案通常规定的三联疗法在印度显示最小的阻力，因此是适当的抗H。印度的幽门螺杆菌管理。(C)2015年国际感染和癌症化疗学会。由爱思唯尔有限公司出版。保留所有权利。
Helicobacter pylori-related gastroduodenal diseases are very common in India. Antibiotic resistance to commonly used antibiotics against H. pylori is increasing very rapidly. The aim of this study was to determine the antimicrobial susceptibility patterns of H. pylori strains from India against commonly used antibiotics in H. pylori treatment. Helicobacter pylori were cultured from 68 patients suffering from various gastroduodenal diseases in North India. Minimum inhibitory concentrations (MICs) to different antibiotics were determined by agar dilution. The clinical diagnosis of the 68 patients who were H. pylori culture-positive were gastro-oesophageal reflux disease (GERD) (n = 23), non-erosive reflux disease (NERD) (n = 22), non-ulcer dyspepsia (NUD) (n = 13), antral gastritis (n = 3), duodenal ulcer (n = 2) and others (n = 5). Of the 68 H. pylori isolates, 20 (29.4%) showed no resistance. The prevalence of drug resistance was 70.6%, including resistance to metronidazole (48.5%), furazolidone (22.1%), amoxicillin (17.6%), tetracycline (16.2%) and clarithromycin (11.8%). Dual and multiple drug resistance were found in 26.5% and 8.8% of cases, respectively. In conclusion, more than two-thirds of the isolated H. pylori strains showed resistance to at least one of the antibiotics for H. pylori treatment. Metronidazole resistance was most prevalent amongst the isolates tested. Emergence of dual and multidrug resistance is of great concern and there is an urgent need for regular antibiotic resistance surveillance studies. Amoxicillin-and clarithromycin-based anti-H. pylori regimens commonly prescribed for triple therapy in India show least resistance and hence are appropriate for anti-H. pylori management in India. (C) 2015 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.