Risk factors for pregnancy-associated venous thromboembolism in Singapore
Risk factors for pregnancy-associated venous thromboembolism in Singapore
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DOI：
10.1515/jpm-2020-0298
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发表时间：
2021-02-01
影响因子：
2.4
通讯作者：
Tan, Thiam Chye
中科院分区：
文献类型：
--
作者：
Jaya-Bodestyne, Sandra Lynn;Lee, Lai Heng;Tan, Thiam Chye
目的：妊娠相关静脉血栓栓塞（VTE），包括深静脉血栓（DVT）和肺栓塞（PE），与孕产妇死亡和发病风险增加相关。本研究旨在评估妊娠相关 VTE 的潜在危险因素。 方法：在这项病例对照研究中，通过国际疾病分类代码识别患有妊娠相关 VTE 的女性，并纳入 2004 年至 2016 年在新加坡竹脚妇幼医院或新加坡中央医院在妊娠期间或产后六周内客观诊断为 VTE 的女性。对照组，即没有 VTE 的孕妇，是从前瞻性纵向研究中选出的。根据一系列母亲和产科因素计算 VTE 的比值比 (OR)。结果和结论：从 2004 年到 2016 年，使用逻辑回归识别并分析了 89 例妊娠相关 VTE 病例和 926 例对照病例。妊娠相关 VTE 最显着的危险因素是吸烟（OR 5.44，p=0.0002）和早产（OR 5.06，p=0.023）。马来人种、多胎、非0血型和剖腹产也被确定为具有较高风险。这些危险因素应该有助于制定妊娠期和产后期的血栓预防策略，尤其是在新加坡。
Objectives: Pregnancy-associated venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is associated with increased risk of maternal mortality and morbidity. This study aimed to assess potential risk factors for pregnancy-associated VTE.Methods: In this case-control study, women with pregnancy-associated VTE were identified via International Classification of Diseases codes and included if they had been objectively diagnosed with VTE during pregnancy or within six weeks postpartum, from 2004 to 2016, at KK Women's and Children's Hospital or Singapore General Hospital in Singapore. Controls, i.e. pregnant women without VTE, were selected from a prospective longitudinal study. The odds ratio (OR) for VTE was computed for a range of maternal and obstetric factors.Results and conclusions: From 2004 to 2016, 89 cases of pregnancy-associated VTE and 926 controls were identifed and analysed using logistic regression. The most significant risk factors for pregnancy-associated VTE were smoking (OR 5.44, p=0.0002) and preterm delivery (OR 5.06, p=0.023). Malay race, multiparity, non-0 blood group and caesarean section, were also identified to be of higher risk. These risk factors should be useful in the development of thromboprophylaxis strategies for pregnancy and the postpartum period, especially in Singapore.