Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma
Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma
复制标题
DOI：
10.1002/cncr.23183
复制
发表时间：
2008-01-15
期刊：
影响因子：
6.2
通讯作者：
Chen, Changhu
中科院分区：
文献类型：
--
作者：
Rusthoven, Kyle;Ballonoff, Ari;Chen, Changhu
背景本研究的目的是比较生存的口腔舌鳞状细胞癌（SCC）患者与SCC患者在其他口腔subsites.METHODS患者的第一和第二阶段（T1-T2 N 0 M0）诊断的口腔SCC在1988年和2004年之间进行了查询，使用监测，流行病学和最终结果（SEER）数据库。采用log-rank检验比较口腔舌鳞癌患者与口腔其他亚部位鳞癌患者的总生存期（OS）和病因特异性生存期（CSS）。进行考克斯比例风险多变量分析，以评估协变量对CSS和OS的风险的影响。结果1988年至2004年，6791例I期和II期口腔鳞状细胞癌患者被确定。其中口腔舌鳞癌占40%，口腔其他部位鳞癌占60%。患者年龄中位数为64岁。口腔舌鳞癌患者的5年OS和CSS率分别为60.9%和83.5%，而其他口腔亚部位SCC患者的5年OS和CSS率分别为64.7%和94.1%（OS：风险比，1.24; P <0.0001; CSS：风险比，3.04; P <0.0001）。多因素分析显示，T分期、年龄、性别、舌质部位对OS和CSS有显著影响。CSS的患者谁有第一和第二阶段的口腔舌鳞状细胞癌也是不利的阶段相匹配的患者谁有SCC的其他头和颈部sites.CONCLUSIONS口腔舌鳞状细胞癌与其他口腔和头颈部网站相比，生存率低。这些数据表明，多模式治疗在该患者队列中具有潜在获益。
BACKGROUND The objective of this study was to compare survival in patients with squamous cell carcinoma (SCC) of the oral tongue with that in patients with SCC in other oral cavity subsites.METHODS Patients with stage I and II (T1-T2N0M0) SCC of the oral cavity diagnosed between 1988 and 2004 were queried by using the Surveillance, Epidemiology, and End Results (SEER) database. The log-rank test was used to compare the overall survival (OS) and cause-specific survival (CSS) of patients who had oral tongue SCC with those of patients who had SCC of other oral cavity subsites. A Cox proportional hazards multivariate analysis was performed to evaluate the influence of covariates on the risk of CSS and OS.RESULTS Between 1988 and 2004, 6791 patients with stage I and II SCC of the oral cavity were identified. Among them, 40% had oral tongue SCC, and 60% had SCC of other oral cavity subsites. The median patient age was 64 years. The 5-year OS and CSS rates were 60.9% and 83.5%, respectively, for patients with oral tongue SCC versus 64.7% and 94.1%, respectively, for patients with SCC of other oral cavity subsites (OS: hazard ratio, 1.24; P < .0001; CSS: hazard ratio, 3.04; P < .0001). On multivariate analysis, OS and CSS were influenced significantly by T classification, age, sex, and oral tongue subsite. The CSS for patients who had stage I and II oral tongue SCC also was unfavorable compared with the CSS for stage-matched patients who had SCC of other head and neck sites.CONCLUSIONS Oral tongue SCC was associated with poor survival compared with other oral cavity and head and neck sites. These data suggested a potential benefit for multimodality therapy in this cohort of patients.