Impulsive and Compulsive Behaviors in Parkinson's Disease
Impulsive and Compulsive Behaviors in Parkinson's Disease
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DOI：
10.1146/annurev-clinpsy-032813-153705
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Djamshidian, A.
中科院分区：
文献类型：
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作者：
Averbeck, B. B.;O'Sullivan, S. S.;Djamshidian, A.
帕金森病（PD）的冲动强迫行为（ICBs）是多巴胺替代疗法的常见和破坏性副作用。在这篇综述中，我们描述了帕金森病患者的现象学，患病率和危险因素。评估PD患者神经心理学特征的行为研究结果强调，ICBs是行为成瘾，不是享乐动机。相反，其他因素，如无法应对不确定性，可能会触发国际竞争性银行。功能成像研究的新见解，加强激励显着性假说，进行了讨论，并给出了治疗指南的管理在PD的ICBs。
Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.