CYTOLOGY OF SYNOVIAL EFFUSIONS IN EPIDEMIC POLYARTHRITIS
CYTOLOGY OF SYNOVIAL EFFUSIONS IN EPIDEMIC POLYARTHRITIS
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DOI：
10.1111/j.1445-5994.1981.tb04226.x
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
LEACH, R
中科院分区：
文献类型：
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作者：
FRASER, JRE;CUNNINGHAM, AL;LEACH, R
对8例Ross Fiver病毒感染后的流行性多发性关节炎患者进行的滑液检查显示，细胞计数在1500-13800个/mm~3之间。染色涂片显示中性粒细胞稀少，单核细胞和空泡巨噬细胞比例高；进一步用光学显微镜和EM观察其特征。4例病程早期的单核细胞和巨噬细胞用特异性免疫荧光法检测到Ross River病毒抗原，EM和细胞培养均未检出完整病毒。在任何细胞类型中均未检测到补体、免疫球蛋白M或免疫球蛋白的细胞相关C3成分。细胞计数和简单涂片可能有助于疑似流行性多发性关节炎的早期诊断，并提供与这种疾病的发病机制相关的进一步信息。
Examination of synovial fluid in 8 patients with epidemic polyarthritis following Ross Fiver virus infection showed cell counts ranging from 1500-13,800/mm3. Stained smears were notable for a paucity of neutrophils and high proportions of monocytes and vacuolated macrophages; they were further characterized by light microscopy and EM. Ross River virus antigen was detected by specific immunofluorescence in monocytes and macrophages of 4 cases early in the course of the illness; intact virus was not identified by EM or cell culture. No cell-associated C3 component of complement, IgM or IgG was detected in any cell-type. Cell counts and simple smears may be useful in the early diagnosis of suspected epidemic polyarthritis and provide further information pertinent to the pathogenesis of this disease.