The origin of a human chorionic gonadotropin beta-subunit-core fragment excreted in the urine of patients with cancer.
The origin of a human chorionic gonadotropin beta-subunit-core fragment excreted in the urine of patients with cancer.
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癌症患者尿液中分泌的人绒毛膜促性腺激素 β 亚基核心片段的起源。
DOI：
10.1530/acta.0.1120415
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Nicopoulou
中科院分区：
文献类型：
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作者：
P. Papapetrou;S. Nicopoulou
采用Sephadex G-100色谱分析了4例癌症患者尿液和肿瘤提取物中免疫反应性人绒毛膜促性腺激素（hCG）及其亚基和hCG β -核心片段。选择这些患者进行调查是因为他们在尿液中排泄了大量的hCG -核心片段。尽管总免疫反应性尿hCG的30-85%是hCG β片段，但仅在两个肿瘤中发现了该片段的痕迹（占总hCG的2%），而在其他两个肿瘤中没有发现。肿瘤中hCG的主要分子形式是hCG的完整游离β亚基。结论是，在一些癌症患者的尿液中发现的hCG β核片段并不是肿瘤的分泌产物。这个片段很可能是由肿瘤分泌的hCG的游离β亚基的外周降解产物。
Immunoreactive human Chorionic Gonadotropin (hCG), its subunits and hCG beta-core fragment were analyzed, using Sephadex G-100 chromatography, in urine and tumour extracts from four patients with cancer. These patients were selected for investigation because they were excreting proportionally large amounts of the hCG beta-core fragment in their urine. Although 30-85% of the total immunoreactive urinary hCG was hCG beta fragment, traces of the fragment (2% of total hCG) were found in only two of the tumours and none in the other two. The predominant molecular form of hCG in the tumours was intact free beta-subunit of hCG. The conclusion is that the hCG beta-core fragment found in the urine of some patients with cancer is not a secretion product of the tumours. This fragment is very likely a peripheral degradation product of the free beta-subunit of hCG which is secreted by the tumours.