The KSR2-rs7973260 Polymorphism is Associated with Metabolic Phenotypes, but Not Psychological Phenotypes, in Chinese Elders
The KSR2-rs7973260 Polymorphism is Associated with Metabolic Phenotypes, but Not Psychological Phenotypes, in Chinese Elders
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在中国老年人中，KSR2-rs7973260 多态性与代谢表型相关，但与心理表型无关
DOI：
10.1089/gtmb.2016.0402
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发表时间：
2017
影响因子：
1.4
通讯作者：
Jiang Xiao-Yan
中科院分区：
文献类型：
--
作者：
Wang Yong;Ma Teng;Zhu Yin-Sheng;Chu Xue-Feng;Yao Shun;Wang Hong-Fei;Cai Jian;Wang Xiao-Feng;Jiang Xiao-Yan
目的：研究最近在白种人中进行的一项全基因组关联研究中发现的ksr2 （RAS激酶抑制因子）-rs7973260、RAPGEF6（鸟嘌呤核苷酸交换因子6）-rs3756290、LOC105377703-rs4481363基因变异与中国老年人主观幸福感（SWB）和抑郁症状（DSs）之间的关系。并探讨了ksr2 -rs7973260对代谢表型的多效性作用。材料和方法：我们使用了1788名年龄在70-84岁之间的老年人的数据，这些数据来自如皋长寿与老龄化研究的老龄化组，这是一项在中国江苏省进行的基于人群的队列研究。结果：在生活满意组和生活不满意组之间，三种多态性的基因型频率没有显著分布。三种变异基因型的主观幸福感成分（积极情绪、消极情绪和情绪平衡）和主观幸福感水平无显著差异。然而，ksr2 -rs7973260的GA+AA在代谢综合征（MetS）、严重高甘油三酯血症（HTG）和糖尿病组中的存在明显高于对照组（分别为43.7%对37.6%、46.4%对37.6%、45.8%对37.9%）。rs7973260等位基因A与met、重度HTG和糖尿病风险增加相关，比值比（95%置信区间）分别为1.289（1.002-1.658）、1.438（1.076-1.921）和1.384(1.022-1.875)，经多次调整后仍具有显著性。结论：Rs7973260、rs3756290和rs4481363与中国老年人SWB和DSs无关。然而，ksr2 - rs7973260a等位基因在中国老年人的一些代谢表型中表现出多效性。这些影响应该在未来的研究中得到验证。
Objective:To examine the associations between genetic variants ofKSR2(kinase suppressor of RAS)-rs7973260,RAPGEF6(guanine nucleotide exchange factor 6)-rs3756290,LOC105377703-rs4481363, and subjective well-being (SWB) and depressive symptoms (DSs) in Chinese elders, which were recently associated in a genome-wide association study conducted in Caucasians. The pleiotropic effects ofKSR2-rs7973260 on metabolic phenotypes were also explored.Materials and Methods:We used data from 1788 older individuals aged 70–84 years from the aging arm of the Rugao Longevity and Aging Study, a population-based cohort study conducted in the Jiangsu province of China.Results:No significant distributions of genotype frequencies were observed between life-satisfied and -unsatisfied groups across those with the three polymorphisms. The level of SWB components (positive affect, negative affect, and affect balance) and DSs did not differ among genotypes of the three variants. However, the presence of GA+AA ofKSR2-rs7973260 was significantly higher in the metabolic syndrome (MetS), severe hypertriglyceridemia (HTG), and diabetes groups than in control groups (43.7% vs. 37.6%, 46.4% vs. 37.6%, 45.8% vs. 37.9%, respectively). The A allele of rs7973260 was associated with increased risk of MetS, severe HTG, and diabetes with an odds ratios (95% confidence intervals) of 1.289 (1.002–1.658), 1.438 (1.076–1.921), and 1.384 (1.022–1.875), which remained significant after multiple adjustments.Conclusion:Rs7973260, rs3756290, and rs4481363 were not associated with SWB and DSs in Chinese elders. However, theKSR2-rs7973260 A allele exhibited pleiotropic effects on some metabolic phenotypes in Chinese elders. These effects should be validated in future studies.