Modulation of the cytoplasmic functions of mammalian post-transcriptional regulatory proteins by methylation and acetylation: a key layer of regulation waiting to be uncovered?
Modulation of the cytoplasmic functions of mammalian post-transcriptional regulatory proteins by methylation and acetylation: a key layer of regulation waiting to be uncovered?
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DOI：
10.1042/bst20150172
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发表时间：
2015-12-01
影响因子：
3.9
通讯作者：
Brook, Matthew
中科院分区：
文献类型：
--
作者：
Blee, Tajekesa K. P.;Gray, Nicola K.;Brook, Matthew
基因表达的转录后控制对于正常的细胞功能和活力是至关重要的，并且介导转录后控制的许多蛋白质本身受到翻译后修饰（PTM）（例如磷酸化）的调节。然而，蛋白质组范围的研究揭示了哺乳动物蛋白质PTM状态的新的复杂性，特别是大量新的甲基化和乙酰化残基正在被鉴定。在这里，我们回顾了甲基化/乙酰化依赖的调节转录后调节蛋白（PTRP）功能的研究实例，并整理了PTM数据，指出这些PTM调节mRNA命运的巨大潜力。
Post-transcriptional control of gene expression is critical for normal cellular function and viability and many of the proteins that mediate post-transcriptional control are themselves subject to regulation by post-translational modification (PTM), e.g. phosphorylation. However, proteome-wide studies are revealing new complexities in the PTM status of mammalian proteins, in particular large numbers of novel methylated and acetylated residues are being identified. Here we review studied examples of methylation/acetylation-dependent regulation of post-transcriptional regulatory protein (PTRP) function and present collated PTM data that points to the huge potential for regulation of mRNA fate by these PTMs.