Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury
Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury
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ICU脑外伤患者血清钠浓度与死亡率的关系评估
DOI：
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发表时间：
2018
影响因子：
0.6
通讯作者：
Mahnaz Shahali
中科院分区：
文献类型：
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作者：
Babak Ali Kiaei;Darioush Moradi Farsani;K. Ghadimi;Mahnaz Shahali
背景：创伤性脑损伤（TBI）是全球死亡和残疾的主要原因，而血清钠紊乱是神经系统疾病中最常见且可能是人们最了解的电解质紊乱。目的：本研究旨在评估TBI患者的血清钠水平及其低钠血症和高钠血症等疾病，并评估入院时、入院第一周和入院后第二周的钠水平。方法：这项观察性前瞻性描述性分析研究纳入了 2015 年至 2016 年入住伊朗伊斯法罕 Saint Al-Zahra 医院重症监护病房 (ICU) 的 TBI 患者。患者的人口统计学因素、血流动力学和临床旁数据记录在信息表中，并导入 SPSS v.22 并使用 SPSS v.22 进行分析。所有统计测试均在 5% 的误差水平下进行。结果：在研究的第一周和第二周，死亡患者与康复或存活个体之间的人口统计指数没有显着差异。结果发现，第一周死亡患者血清钠平均值为146.26 mEq/L，存活患者血清钠平均值为142.66 mEq/L（P < 0.001）；第二周死亡患者血清钠平均值为147.8 mEq/L，存活患者血清钠平均值为144.03 mEq/L（P < 0.001）。结论：入住 ICU 的患有钠血症的 TBI 患者死亡率较高，可显着增加死亡风险。高钠血症的死亡风险明显高于低钠血症。
Background: Traumatic brain injury (TBI) is a major cause of death and disability globally, and serum sodium disorders are the most common and probably the most poorly understood electrolyte disorders in neurological diseases. Objectives: The aim of this study was to evaluate the serum sodium level and its disorders including hyponatremia and hypernatremia in patients with TBI and evaluate the sodium levels at the time of admission, the first week, and the second week after admission. Methods: This observational prospective descriptive-analytic study included patients with TBI admitted to the intensive care unit (ICU) of Saint Al-Zahra hospital, Isfahan, Iran during 2015 - 2016. Patients’ demographic factors, hemodynamic and paraclinical data were documented in the information forms and imported to and analyzed using SPSS v.22. All of the statistical tests were conducted at an error level of 5%. Results: Demographic indices were not significantly different in the first and second weeks of the study between patients who died and the recovered or survived individuals. It was found that the mean of serum sodium was 146.26 mEq/L in patients who died and 142.66 in alive patients (P < 0.001) in the first week and 147.8 in the patients who died and 144.03 in alive patients (P < 0.001) in the second week. Conclusions: The mortality prevalence of patients with TBI admitted to the ICU who have dysnatremia is high and can increase the risk of mortality remarkably. The mortality risk of hypernatremia is significantly higher than that of hyponatremia.