Micronutrients Drift During Daily and Weekly Iron Supplementation in Non-anaemic and Anaemic Pregnancy
Micronutrients Drift During Daily and Weekly Iron Supplementation in Non-anaemic and Anaemic Pregnancy
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DOI：
10.1007/s12291-017-0634-9
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发表时间：
2017-10-01
影响因子：
2.1
通讯作者：
Rao, D. N.
中科院分区：
文献类型：
--
作者：
Shankar, Hari;Kumar, Neeta;Rao, D. N.
目的 怀孕是一种与身体生理、心理和生化状态动态变化相关的现象，需要增加胎儿发育所需的营养摄入。作为抗氧化酶的辅助因子或其本身作为抗氧化剂的各种微量营养素的水平随着怀孕的进展而改变。本纵向研究总结了贫血（AP）和非贫血初产妇（NAP）在怀孕期间和产后每日和每周口服铁叶酸（IFA）片剂的选定微量营养素水平的趋势。方法 总共 200 名初产妇{N = 100;招募 NAP (Hb > 11 g/dl) 和 N = 100 AP (Hb = 8-11 g/dl) 每日 (N = 50) 和每周 (N = 50) 补充，并在产后 3 个月和 6 周后、第 13-16 周时抽取隔夜禁食血样。通过电感耦合等离子体原子发射分光光度计估算血清铁、铜、锌、镁和锰。 结果 NAP 和每日补充 IFA 片剂的 AP 之间，基线时的血清锰 (p < 0.05) 和产后的镁 (p < 0.01) 存在显着差异。两组的铜含量在怀孕期间均有所增加，而在产后则有所下降。每日补充铁会导致妊娠晚期 NAP 中的铁含量显着升高 (p < 0.05)。结论 贫血妊娠中每周补充 IFA 和每日补充 IFA 时分别观察到低锌血症和低镁血症。清楚的证据表明，健康妊娠和贫血妊娠期间微量营养素水平发生了变化。本研究可为孕期营养评估提供参考值，以实现健康妊娠结局。
Aims Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum.Methods A total of 200 primigravida {N = 100; NAP (Hb > 11 g/dl) and N = 100 AP (Hb = 8-11 g/dl) assigned daily (N = 50) and weekly (N = 50) supplementation} were recruited and overnight fasting blood samples were withdrawn at 13-16 weeks, after 3 months and 6 weeks postpartum. The serum iron, copper, zinc, magnesium and manganese were estimated by inductively coupled plasma-atomic emission spectrophotometer.Results Serum manganese (p < 0.05) at baseline and magnesium (p < 0.01) at postpartum was significantly different between NAP and AP supplemented with daily IFA tablets. The trend of copper found to be increased during pregnancy and later declined at postpartum in both the groups. Daily supplementation resulted in significantly high iron (p < 0.05) in NAP during third trimester.Conclusion sHypozincemia and hypomagnesemia was observed in anaemic pregnancy supplemented with weekly and daily IFA respectively. Clear evidence of altered micronutrients levels during healthy and anaemic pregnancy was seen. The reference values may be drawn from this study for the nutritional assessment during pregnancy for healthy pregnancy outcomes.