The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.
The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.
复制标题
NTS2 在低温和热镇痛小鼠模型中 NT69L 耐受性发展中的作用。
DOI：
10.1016/j.bbr.2011.06.014
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发表时间：
2011
影响因子：
2.7
通讯作者：
Richelson,Elliott
中科院分区：
文献类型：
--
作者：
Smith,KristinE;Boules,Mona;Williams,Katrina;Fauq,AbdulH;Richelson,Elliott
NT69L 是一种神经降压素 (NT)(8-13) 类似物，可结合两种主要 NT 受体 NTS1 和 NTS2，并引发与内源性 NT 类似的行为效应。 NT69L 的某些效应（但不是全部）的耐受性迅速发展，迄今为止，人们对造成这种耐受性的机制知之甚少。 NTS1 介导的行为效应（包括低温和热镇痛）似乎比 NTS2 介导的行为效应更普遍出现耐受性。然而，我们假设 NTS1 和 NTS2 在介导 NT69L 的作用中发挥重要作用。在这里，我们利用 NTS2 敲除小鼠研究了 NTS2 对 NT69L 介导的低温和热镇痛的作用。我们表明，野生型（WT）小鼠在亚慢性治疗后会出现对 NT69L 介导的低温和热镇痛的耐受性，并且 NTS2 对于这种耐受性的发展是必需的。此外，我们还提出了 NTS2 影响这些 NT69L 介导的行为的潜在方法。
NT69L is a neurotensin (NT)(8-13) analog that binds the two major NT receptors, NTS1 and NTS2, and elicits similar behavioral effects as endogenous NT. Tolerance develops rapidly to some, but not to all of NT69L's effects, and to date, little is known about the mechanisms responsible for this tolerance. The development of tolerance appears to be more prevalent in behavioral effects mediated by NTS1 than by those mediated by NTS2, including hypothermia and thermal analgesia. However, we hypothesize that both NTS1 and NTS2 have important roles in mediating the effects of NT69L. Here, we investigate the role of NTS2 on NT69L-mediated hypothermia and thermal analgesia with the use of NTS2 knock-out mice. We show that tolerance develops to NT69L-mediated hypothermia and thermal analgesia following sub-chronic treatment in wild-type (WT) mice, and that NTS2 is necessary for the development of that tolerance. Additionally, we suggest potential means by which NTS2 influences these NT69L-mediated behaviors.