Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes
Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes
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DOI：
10.1016/j.numecd.2006.07.001
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发表时间：
2007-09-01
影响因子：
3.9
通讯作者：
Marchesini, Giulio
中科院分区：
文献类型：
--
作者：
Manini, Rita;Forlani, Gabriele;Marchesini, Giulio
背景和目的：与中性鱼精蛋白Hagedorn （NPH）胰岛素相比，甘精氨酸改善血糖控制，降低夜间低血糖的风险。迄今为止，只有一项研究测量了甘精对健康相关生活质量（HRQL）的影响；因此，本研究的目的是确认甘精氨酸对1型糖尿病疾病特异性HRQL的有益作用。方法和结果：47例糖尿病患者（平均年龄46岁，25-74岁，男性54%）病程至少1年，在胰岛素强化治疗（IIT）下血糖控制不佳，从NPH切换到甘精。40例维持IIT的患者作为对照。糖尿病相关的HRQL在切换到甘精6- 8个月之前和之后使用糖尿病患者健康调查（WED）进行评估。一份基于糖尿病特定问题的11项问卷用于评估治疗满意度和转换后的感知变化。在甘精治疗组中，平均糖化血红蛋白降低了0.7%（治疗组与基线组相比，P < 0.0001），几个WED评分有所改善（不适，P = 0.020；影响，P = 0.0002；总分，P = 0.0005）。WED的改变与高血糖的感知风险和日常生活中较少的甘精氨酸问题相关。结论：本研究结果表明。甘精氨酸的有益作用不仅限于更好的代谢控制；1型糖尿病对日常生活的负担也减轻了。(c) 2006 Elsevier B.V.版权所有
Background and aims: Glargine improves glucose control and reduces the risk of nocturnal hypoglycemia compared with neutral protamine Hagedorn (NPH) insulin. To date, only one study has measured the effects of glargine on health-related quality of life (HRQL); the aim of this study was therefore to confirm the beneficial effects of glargine on disease-specific HRQL in type 1 diabetes.Methods and results: Forty-seven patients (mean age, 46 range, 25-74; mates, 54%) with diabetes of at least 1-year duration, and with suboptimal glucose control under intensive insulin treatment (IIT), were switched from NPH to glargine. Forty patients maintained on IIT were used as controls. Diabetes-related HRQL was assessed using the Well-being Enquiry for Diabetics (WED), before and after a 6- to 8-month switch to glargine. An 11-item questionnaire based upon diabetes-specific issues was used to assess treatment satisfaction and perceived changes after switching.On glargine, the mean glycosylated hemoglobin decreased by 0.7% (treatment vs. baseline, P < 0.0001) and several WED scores improved (discomfort, P = 0.020; impact, P = 0.0002; total score, P = 0.0005). WED changes were associated with a tower perceived risk of hypoglycemia and less problems in daily life on glargine.Conclusions: The results of this study show. that the beneficial effect of glargine is not limited to better metabolic control; the burden of type 1 diabetes mellitus on everyday life is also reduced. (c) 2006 Elsevier B.V. All rights reserved.