Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas
Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas
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DOI：
10.1111/j.1440-1827.2006.01985.x
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发表时间：
2006-08-01
影响因子：
2.2
通讯作者：
Noguchi, Masayuki
中科院分区：
文献类型：
--
作者：
Takeuchi, Tomoyo;Minami, Yuko;Noguchi, Masayuki
肺大细胞神经内分泌癌（LCNEC）是一个新的实体。除形态学特征外，其分子生物学特征已被许多研究者研究，并与其他神经内分泌癌、小细胞肺癌（SCLC）和类癌（CT）进行了比较。然而，很少有报道表明它们之间存在显著差异的遗传特征。本文研究了38例肺神经内分泌癌（LCNEC 13例，SCLC 11例，CT 14例）和10例肺大细胞癌（LCC）中染色体3 p（3p14.2）的杂合性丢失（洛）频率。3p14.2位点洛缺失率在LCNEC、SCLC、LCC和CT中分别为69.2%、81.8%、50.0%和7.14%。22q13.3在LCNEC、SCLC、LCC和CT中的阳性率分别为30.8%、72.7%、45.5%和7.14%。特别是在3p14.2和22q13.3两个位点均存在洛缺失的SCLC（63.6%）明显高于LCNEC（15.4%）。LCNEC和SCLC在3p14.2和22q13.3的洛合性缺失（LOH）具有不同的特点。联合分析3p14.2和22q13.3的洛缺失有助于LCNEC和SCLC的鉴别诊断。
Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2% in LCNEC, 81.8% in SCLC, 50.0% in LCC and 7.14% in CT. Those at 22q13.3 were 30.8% in LCNEC, 72.7% in SCLC, 45.5% in LCC and 7.14% in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6%) was significantly higher than that of LCNEC (15.4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.