Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson's disease
Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson's disease
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DOI：
10.1016/j.clineuro.2005.07.008
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发表时间：
2006-07-01
影响因子：
1.9
通讯作者：
Pahwa, Rajesh
中科院分区：
文献类型：
--
作者：
Davis, Justin T.;Lyons, Kelly E.;Pahwa, Rajesh
目的：探讨双侧丘脑底核（STN）深部脑刺激（DBS）对帕金森病患者步态冻结的远期影响。患者与方法：67例患者术后12个月随访，32例患者术后24个月随访。用统一帕金森病评定量表（UPDRS）对患者进行评估，在基线时开药和停药，在随访时两种情况下再次进行刺激。特别注意的是ADL切片的冻结项。结果：停药后1年和2年冷冻评分均有明显改善。在药物状态下，冷冻没有明显的改善。结论：STN DBS可显著改善24个月的间歇冻结步态；然而，周期冻结不受STN DBS的影响。(c) 2005 Elsevier B.V.版权所有
Objective: To determine the long-term effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on freezing of gait in Parkinson's disease patients.Patients and methods: Sixty-seven patients were followed 12 months after bilateral STN DBS and 32 patients were followed 24 months post-surgery. Patients were evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS) with medications on and off at baseline and again in both conditions with stimulation on at follow-up. Specific attention was paid to the freezing item of the ADL section.Results: Freezing scores in the medication off state improved significantly with stimulation at 1 and 2 years. In the medication on state there were no significant improvements in freezing.Conclusion: Off period freezing of gait is significantly improved with STN DBS up to 24 months; however, on period freezing is not affected by STN DBS. (c) 2005 Elsevier B.V. All rights reserved.