Epigenetic differences between sister chromatids?
Epigenetic differences between sister chromatids?
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DOI：
10.1111/j.1749-6632.2012.06505.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Naumann, Ulrike
中科院分区：
文献类型：
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作者：
Lansdorp, Peter M.;Falconer, Ester;Naumann, Ulrike
半保守复制可确保姐妹染色单体的 DNA 序列相同，但复制错误以及复制丢失和可变末端加工导致的端粒重复长度变化除外。 DNA复制过程中各种表观遗传标记会发生什么还不太清楚。许多染色质标记可能与 DNA 复制一起复制到两个姐妹染色单体上，而其他标记可能随机分布在姐妹染色单体之间。姐妹染色单体之间的表观遗传差异也可能以更可预测的方式出现，例如，遵循与滞后链 DNA 复制相关的过程。姐妹染色单体之间由此产生的表观遗传差异可能导致子细胞中不同的基因表达模式。这种可能性很难测试，因为区分亲本姐妹染色单体的技术需要对单细胞进行分析并且并不明显。在这里，我们简要回顾了姐妹染色单体表观遗传学的主题，并讨论了细胞中姐妹染色单体的识别如何改变我们对不对称细胞分裂以及一般细胞和特别是配对子细胞之间基因表达随机变异的看法。
Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear. Many chromatin marks are likely to be copied onto both sister chromatids in conjunction with DNA replication, whereas others could be distributed randomly between sister chromatids. Epigenetic differences between sister chromatids could also emerge in a more predictable manner, for example, following processes that are associated with lagging strand DNA replication. The resulting epigenetic differences between sister chromatids could result in different gene expression patterns in daughter cells. This possibility has been difficult to test because techniques to distinguish between parental sister chromatids require analysis of single cells and are not obvious. Here, we briefly review the topic of sister chromatid epigenetics and discuss how the identification of sister chromatids in cells could change the way we think about asymmetric cell divisions and stochastic variation in gene expression between cells in general and paired daughter cells in particular.