CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE MEDIATES A PATHWAY FOR TRANSCRIPTIONAL REGULATION
CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE MEDIATES A PATHWAY FOR TRANSCRIPTIONAL REGULATION
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DOI：
10.1073/pnas.88.9.3710
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
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作者：
KAPILOFF, MS;MATHIS, JM;ROSENFELD, MG
细胞外信号引起的钙离子内流可以调节基因转录。II型钙/钙调蛋白依赖蛋白激酶的结构性、钙/钙调素非依赖性突变体能够提高特定基因的转录速率，而不依赖于蛋白激酶C的激活。这种增加是由能够结合转录因子CAAT/增强子结合蛋白的可转移顺式活性元件介导的。因此，在钙离子介导的基因转录调控中，激活II型钙/钙调蛋白依赖的蛋白激酶，以响应细胞内钙的增加，被认为是一种独特的第二信使途径。
Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.