Increased Levels of Serum Pentraxin 3, a Novel Cardiovascular Biomarker, in Patients With Inflammatory Rheumatic Disease
Increased Levels of Serum Pentraxin 3, a Novel Cardiovascular Biomarker, in Patients With Inflammatory Rheumatic Disease
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DOI：
10.1002/acr.20094
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发表时间：
2010-03-01
影响因子：
4.7
通讯作者：
Meroni, Pier Luigi
中科院分区：
文献类型：
--
作者：
Hollan, Ivana;Bottazzi, Barbara;Meroni, Pier Luigi
目标。penttraxin 3 （PTX3）是先天性免疫的关键组成部分，是冠状动脉疾病（CAD）疾病严重程度的重要标志。本研究的目的是比较伴有和不伴有炎症性风湿病（IRD）的CAD患者与健康对照者的血清PTX3水平。我们研究了69例有IRD （CAD/IRD组）和53例无IRD （CAD/非IRD）的冠状动脉搭桥术患者，以及30名健康对照。CAD/IRD组平均+/- SD血清PTX3水平为1.96 +/- 0.98 ng/ml；与冠心病/非ird组（1.41 +/- 0.74 ng/ml）和健康对照组（1.21 +/- 0.59 ng/ml）相比，差异有统计学意义。与大多数其他ird相比，系统性红斑狼疮（SLE）和其他系统性结缔组织疾病患者的血清PTX3水平相对较低。在性别和年龄校正分析中，IRD、急性冠状动脉综合征和低酒精摄入量与较高的血清PTX3水平相关。冠心病合并IRD患者的平均血清PTX3水平高于无IRD患者和健康对照组。此外，急性冠状动脉综合征和低酒精摄入量独立预测血清PTX3水平升高。IRD患者血清PTX3水平升高可能与IRD患者心血管风险升高有关。循环PTX3可能用作ird患者心血管疾病严重程度的生物标志物；然而，它在SLE和相关疾病中的重要性可能有限。
Objective. Pentraxin 3 (PTX3), a key component of innate immunity, is a strong marker of disease severity in coronary artery disease (CAD). The aim of this study was to compare levels of serum PTX3 in CAD patients with and without inflammatory rheumatic disease (IRD) and in healthy controls.Methods. We examined 69 patients with IRD (CAD/IRD group) and 53 patients without IRD (CAD/non-IRD) referred to coronary artery bypass grafting, and 30 healthy controls.Results. The mean +/- SD serum PTX3 level in the CAD/IRD group was 1.96 +/- 0.98 ng/ml; this was statistically significantly higher than that of the CAD/non-IRD (1.41 +/- 0.74 ng/ml) and healthy control (1.21 +/- 0.59 ng/ml) groups. In contrast to most other IRDs, serum PTX3 levels were relatively low in patients with systemic lupus erythematosus (SLE) and other systemic connective tissue diseases. In sex-and age-adjusted analysis, IRD, acute coronary syndromes, and low alcohol intake were associated with higher serum PTX3 levels.Conclusion. CAD patients with IRD had higher mean serum PTX3 levels than patients without IRD and healthy controls. In addition, acute coronary syndromes and low alcohol intake independently predicted higher serum PTX3 levels. Higher serum PTX3 levels in IRD may be related to the higher cardiovascular risk of IRD patients. Circulating PTX3 could likely be used as a biomarker for severity of cardiovascular disease in IRDs; its importance, however, might be limited in SLE and related disorders.