A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination
A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination
复制标题
DOI：
10.1038/nn.4425
复制
发表时间：
2017-01-01
影响因子：
25
通讯作者：
Nave, Klaus-Armin
中科院分区：
文献类型：
--
作者：
Goebbels, Sandra;Wieser, Georg L.;Nave, Klaus-Armin
The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide P1(3,4,5)P-3 is sufficient to trigger all steps of myelination.
