Molecular epidemiology of human immunodeficiency virus type 1 sub-subtype A3 in Senegal from 1988 to 2001.
Molecular epidemiology of human immunodeficiency virus type 1 sub-subtype A3 in Senegal from 1988 to 2001.
复制标题
1988年至2001年塞内加尔人类免疫缺陷病毒1型A3亚型的分子流行病学。
DOI：
10.1128/jvi.78.22.12455-12461.2004
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发表时间：
2004
影响因子：
5.4
通讯作者：
Kanki,PhyllisJ
中科院分区：
文献类型：
--
作者：
Meloni,SeemaThakore;Sankalé,Jean-Louis;Hamel,DonaldJ;Eisen,Geoffrey;Guéye-Ndiaye,Aissatou;Mboup,Souleymane;Kanki,PhyllisJ
全球人类免疫缺陷病毒（艾滋病毒）流行病的特点是流行病毒的遗传多样性很大。我们最近确定了一组病毒的特征，这些病毒在A亚型辐射中形成了一个独特的亚亚型，我们将其命名为在西非流行的HIV 1型（HIV-1）亚亚型A。一项对塞内加尔达喀尔一群女性性工作者（FSW）进行的为期18年的前瞻性研究表明，在46名HIV-1感染妇女中发现了env基因C2-V3区的A3特异性序列。HIV-1亚型A3早在1988年就出现在FSW人群中，并在2001年继续传播。我们还发现，HIV-1 A3不仅限于塞内加尔的FSW队列，而且还在达喀尔的普通人群中传播。此外，对来自其他几个西非和中非国家的病毒序列的分析也证明了在象牙海岸、尼日利亚、尼日尔、几内亚比绍、贝宁和赤道几内亚的HIV-1感染者分离物中存在HIV-1 A3序列的证据。总的来说，由于在塞内加尔的一般人群中存在A3亚型的证据，以及在一些邻近的西非和中非国家，沿着达喀尔高危FSW人群中含A3病毒感染的发病率增加，我们认为区分和监测HIV-1 A3亚型病毒很重要。
The global human immunodeficiency virus (HIV)epidemic is characterized by significant genetic diversity in circulating viruses. We have recently characterized a group of viruses that form a distinct sub-subtype within the subtype A radiation, which we have designated HIV type 1 (HIV-1) sub-subtype A, circulating in West Africa. A prospective study of a cohort of female sex workers (FSW) in Dakar, Senegal over an 18-year period indicated that an A3-specific sequence in the C2-V3 region of the env gene was found in 46 HIV-1-infected women. HIV-1 sub-subtype A3 appeared in the FSW population as early as 1988 and continued to be transmitted as of 2001. We also found that HIV-1 A3 is not confined to the FSW cohort in Senegal but is also circulating in the general population in Dakar. Furthermore, analyses of viral sequences from a few other West and Central African countries also demonstrated evidence of HIV-1 A3 sequence in isolates from HIV-1-infected people in Ivory Coast, Nigeria, Niger, Guinea Bissau, Benin, and Equatorial Guinea. Overall, because of the evidence of sub-subtype A3 in the general population in Senegal, as well as in a few neighboring West and Central African countries, along with the increasing incidence of infection with A3-containing viruses in the Dakar high-risk FSW population, we feel that HIV-1 sub-subtype A3 viruses are important to distinguish and monitor.