Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.
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DOI：
10.1016/j.tcb.2016.05.003
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发表时间：
2016-09
影响因子：
19
通讯作者：
Irvine KD
中科院分区：
文献类型：
--
作者：
Sun S;Irvine KD
Hippo信号网络整合了多种上游信号来控制细胞命运决定和调节器官生长。最近的研究为Hippo信号传导的细胞组织、其与细胞间连接的关系以及细胞骨架如何调节Hippo信号传导提供了新的见解。细胞-细胞连接通过定位与该通路核心组分相互作用的支架蛋白作为Hippo信号传导的平台。Hippo通路组分与细胞-细胞连接和细胞骨架的相互作用也提示了通过细胞接触和细胞极性调节该通路的潜在机制。随着我们对Hippo信号复杂性理解的增加，未来的挑战将是了解该途径的不同输入是如何整合的，并定义它们各自在体内的贡献。
The Hippo signaling network integrates diverse upstream signals to control cell fate decisions and regulate organ growth. Recent studies have provided new insights into the cellular organization of Hippo signaling, its relationship to cell-cell junctions, and how the cytoskeleton modulates Hippo signaling. Cell-cell junctions serve as platforms for Hippo signaling by localizing scaffolding proteins that interact with core components of the pathway. Interactions of Hippo pathway components with cell-cell junctions and the cytoskeleton also suggest potential mechanisms for the regulation of the pathway by cell contact and cell polarity. As our understanding of the complexity of Hippo signaling increases, a future challenge will be to understand how the diverse inputs into the pathway are integrated, and to define their respective contributions in vivo.