Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity.
Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity.
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DOI：
10.1016/j.biopsych.2009.03.015
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发表时间：
2009-09-01
影响因子：
10.6
通讯作者：
Critchley HD
中科院分区：
文献类型：
--
作者：
Harrison NA;Brydon L;Walker C;Gray MA;Steptoe A;Critchley HD
炎症细胞因子与抑郁症的病理生理学有关。在啮齿类动物中，全身施用炎症细胞因子会诱发抑郁样行为。同样，在人类中，治疗性干扰素-α 会导致三分之一的患者出现临床抑郁症。相反，抑郁症患者也表现出促炎细胞因子升高。确定炎症相关情绪变化的神经机制以及对参与情绪稳态和情感处理的回路的调节作用。在一项双盲、随机交叉研究中，16 名健康男性志愿者在两次实验中接受了伤寒疫苗接种或生理盐水（安慰剂）注射。在基线以及 2 小时和 3 小时完成情绪问卷。注射后两小时，参与者在功能磁共振成像期间执行隐式情绪面部感知任务。分析的重点是与炎症相关的情绪变化和对情绪表达做出反应并与抑郁症病因有关的区域内的情感处理的神经生物学相关性。伤寒注射液而非安慰剂注射液产生炎症反应，其表现为循环白细胞介素 6 增加和 3 小时后情绪显着下降。炎症相关的情绪恶化与情绪面孔处理过程中膝下前扣带皮层（sACC）（与抑郁症病因有关的区域）内的活动增强相关。此外，炎症相关的情绪变化降低了 sACC 与杏仁核、内侧前额叶皮层、伏隔核和颞上沟的连接性，而该连接性由外周白细胞介素 6 调节。炎症相关的情绪恶化反映在对情绪刺激的诱发反应期间 sACC 活动和功能连接的变化。外周细胞因子调节这种情绪依赖性 sACC 连接，表明重度抑郁症和疾病相关情绪变化和抑郁症存在共同的病理生理学基础。
Inflammatory cytokines are implicated in the pathophysiology of depression. In rodents, systemically administered inflammatory cytokines induce depression-like behavior. Similarly in humans, therapeutic interferon-α induces clinical depression in a third of patients. Conversely, patients with depression also show elevated pro-inflammatory cytokines. To determine the neural mechanisms underlying inflammation-associated mood change and modulatory effects on circuits involved in mood homeostasis and affective processing. In a double-blind, randomized crossover study, 16 healthy male volunteers received typhoid vaccination or saline (placebo) injection in two experimental sessions. Mood questionnaires were completed at baseline and at 2 and 3 hours. Two hours after injection, participants performed an implicit emotional face perception task during functional magnetic resonance imaging. Analyses focused on neurobiological correlates of inflammation-associated mood change and affective processing within regions responsive to emotional expressions and implicated in the etiology of depression. Typhoid but not placebo injection produced an inflammatory response indexed by increased circulating interleukin-6 and significant mood reduction at 3 hours. Inflammation-associated mood deterioration correlated with enhanced activity within subgenual anterior cingulate cortex (sACC) (a region implicated in the etiology of depression) during emotional face processing. Furthermore, inflammation-associated mood change reduced connectivity of sACC to amygdala, medial prefrontal cortex, nucleus accumbens, and superior temporal sulcus, which was modulated by peripheral interleukin-6. Inflammation-associated mood deterioration is reflected in changes in sACC activity and functional connectivity during evoked responses to emotional stimuli. Peripheral cytokines modulate this mood-dependent sACC connectivity, suggesting a common pathophysiological basis for major depressive disorder and sickness-associated mood change and depression.
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DOI：
10.1073/pnas.89.19.9117
发表时间：
1992-10-01
影响因子：
11.1
作者：
KENT, S;BLUTHE, RM;VANNICE, JL
通讯作者：
VANNICE, JL
影响因子：
158.5
作者：
Musselman, DL;Lawson, DH;Miller, AH
通讯作者：
Miller, AH
影响因子：
3.4
作者：
Merali, Z;Brennan, K;Anisman, H
通讯作者：
Anisman, H
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
影响因子：
5.7
作者：
Deichmann, R;Gottfried, JA;Turner, R
通讯作者：
Turner, R