Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis
Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis
复制标题
胃癌中 Th17 细胞的扩增可能有助于癌症的发展和转移
DOI：
10.1007/s12026-013-8483-y
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Xu, Huaxi
中科院分区：
文献类型：
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作者：
Su, Zhaoliang;Sun, Yingkun;Xu, Huaxi
Th 0细胞分化为Th 1或Th 2依赖于多个转录因子在特定时间点作用以调节基因表达。Th 17细胞是产生IL-17的T细胞的一个亚群，与Th 1或Th 2细胞不同，已被描述为炎症和自身免疫性疾病以及癌症发展的关键参与者。本研究选取66例胃癌患者，检测胃癌组织及外周血单个核细胞（PBMC）中Th 1、Th 17相关的IFN-γ、IL-17、T-bet、RORγt的表达水平，分析Th 17、Th 1浸润与胃癌转移的关系，并探讨其可能的机制。结果表明，胃癌组织和PBMC中IL-17和RORγt表达均明显升高，尤其是转移癌患者，血浆IL-17水平也明显升高，IL-1β、IL-21和TGF-β的mRNA和蛋白水平均上调。提示胃癌组织中存在Th 17细胞浸润，IL-1β、IL-21和TGF-β也通过促进Th 17细胞的生成参与胃癌的发生发展。根据以上数据，我们推测胃癌中Th 17细胞的扩增可能有助于癌症的发展和转移。
Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells has been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 66 patients with gastric cancer were included; the expression level of Th1- and Th17-related IFN-γ, IL-17,T-bet, RORγt in gastric cancer tissues and peripheral blood mononuclear cell (PBMC) were detected, analyzed the relationship between Th17 or Th1 infiltration and metastasis and explored the possible mechanism. Our results showed that IL-17 and RORγt expression were significantly increased in gastric cancer tissues and PBMC, especially, in metastasis patients; plasma IL-17 also increased; furthermore, the mRNA and protein levels of IL-1β, IL-21 and TGF-β were up-regulated. All the data indicated that Th17 was infiltrated the cancer tissue; IL-1β, IL-21 and TGF-β were also involved in gastric cancer development by promoting Th17 cell generation. From the above data, we speculated that Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis.