Extragenital adenomatoid tumor of a mediastinal lymph node
Extragenital adenomatoid tumor of a mediastinal lymph node
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DOI：
10.4065/78.3.350
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发表时间：
2003-03-01
影响因子：
8.9
通讯作者：
Chevelle, JC
中科院分区：
文献类型：
--
作者：
Isotalo, PA;Nascimento, AG;Chevelle, JC
腺瘤样瘤是一种良性肿瘤，主要见于男性和女性生殖道。生殖器外腺瘤样瘤常累及浆膜表面和无间皮衬里的器官，如肾上腺。自从腺瘤样瘤被发现以来，其组织发生学起源一直存在争议。许多研究者支持腺瘤样瘤的间皮细胞起源，因为这些肿瘤特征性地表达间皮细胞表型。由于肿瘤的解剖分布，也有人认为肿瘤来源于原始多能间充质细胞和体腔上皮。尽管其特征性间皮瘤表型和组织学外观，腺瘤样肿瘤有广泛的鉴别诊断，包括血管肿瘤，恶性间皮瘤，生殖细胞肿瘤和转移性腺癌。识别这些肿瘤可能是。当在冷冻切片上检查和在罕见的生殖器外部位遇到腺瘤样肿瘤时尤其困难。我们报告一个纵膈淋巴结腺瘤样瘤，是在再次胃成形术中偶然发现的。在冰冻切片检查中，此肿瘤被误诊为转移性腺癌。苏木精-伊红组织学、免疫组化和超微结构研究证实了该肿瘤的间皮细胞表型。据我们所知，这是第一次描述淋巴结腺瘤样瘤。
Adenomatoid tumors are benign neoplasms found predominantly in male and female genital tracts. Rate extragenital adenomatoid tumors have been discovered that involve serosal surfaces and nonmesothelial-lined organs such as adrenal glands. Since the discovery of adenomatoid tumors, their histogenetic: origin has been debated. Many researchers support a mesothelial cell origin for adenomatoid tumors because these tumors characteristically express a mesothelial phenotype. Tumor derivation from primitive pluripotent mesenchymal cells and coelomic epithelium also has been suggested because of the anatomical distribution of the tumors. Despite their characteristic mesothelial phenotype and histological appearance, adenomatoid tumors have an extensive differential diagnosis that includes vascular neoplasms, malignant mesothelioma, germ cell tumors, and metastatic adenocarcinoma. Recognition of these tumors may be. especially difficult when examined at frozen section and when adenomatoid tumors are encountered in rare extragenital sites. We describe an adenomatoid tumor of a mediastinal lymph node that was found incidentally during a redo Collis-Nissen gastroplasty. On frozen section examination, this tumor was misinterpreted as metastatic adenocarcinoma. The hematoxylin-eosin histological, immunohistochemical, and ultrastructural studies confirmed the mesothelial phenotype of this tumor. To our knowledge, this is the first description of a lymph node adenomatoid tumor.