International standards for growth hormone
International standards for growth hormone
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DOI：
10.1159/000053129
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Bristow, AF
中科院分区：
文献类型：
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作者：
Bristow, AF
自1955年以来，世界卫生组织建立了第一个用于生物测定的牛生长激素（GH）国际标准（IS），在GH的标准化方面取得了许多进展。目前有两种生长激素ISs被使用：1982年建立的用于人生长激素的IS和1994年建立的用于生长激素（重组dna衍生的生长激素）的IS。两个这样的标准的可用性并不鼓励不同实验室之间生长激素估计的可重复性。生长激素具有国际公认的3 IU/mg特异性活性的优势，作者建议国际上对生长激素的IS进行验证和采用，作为所有生长激素免疫测定的主要参考标准，最终将消除生长激素估计的这一差异来源。
Since 1955, with the establishment by the World Health Organization of the first International Standard (IS) for bovine growth hormone (GH) for bioassay, there have been a number of developments in the standardization of GH. Two GH ISs are in current use: the IS for human GH established in 1982 and the IS for somatropin (recombinant DNA-derived GH) established in 1994. The availability of two such standards does not encourage reproducibility of GH estimates between different laboratories. The author proposes that the international validation and adoption of the IS for somatropin, which has the advantage of an internationally agreed specific activity of 3 IU/mg, as the primary reference standard for all GH immunoassays would finally eliminate this source of variation in GH estimates.