Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
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DOI：
10.1016/s1097-2765(01)00184-8
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发表时间：
2001-02-01
期刊：
影响因子：
16
通讯作者：
Strutt, DI
中科院分区：
文献类型：
--
作者：
Strutt, DI
果蝇的卷曲基因编码一种跨膜受体分子，这种分子在成体角质层中决定细胞的极性。在翅膀中，每个细胞产生一个单独的毛状体，通常指向远端。在没有卷曲功能的情况下，毛不再均匀地指向远处。我们报告说，在细胞极化过程中，卷曲受体定位于远端细胞边缘，可能导致不对称的卷曲活动跨越细胞轴。此外，卷曲定位与随后的毛状体极性相关，表明它可能是确定细胞极性的指导性线索。这种不同的受体分布可能代表了一种新的机制，可以放大细胞轴上信号活动的微小差异。
The frizzled gene of Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell.