Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.
Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.
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DOI：
10.1016/j.neuron.2013.09.021
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发表时间：
2013-12-18
期刊：
影响因子：
16.2
通讯作者：
Mooney R
中科院分区：
文献类型：
--
作者：
Murugan M;Harward S;Scharff C;Mooney R
FOXP 2基因的突变损害人类的言语和语言发育，而shRNA介导的对鸟类直系同源物FoxP 2的抑制破坏了青少年斑胸草雀的歌曲学习。FoxP 2水平的降低如何影响发声控制，并改变对学习发声重要的神经回路的功能，目前尚不清楚。在这里，我们表明，FoxP 2敲低在鸣禽纹状体破坏发展和社会调制的歌曲的变化。在麻醉鸟类的记录表明，FoxP 2敲低干扰D1 R依赖性调制的活动传播的皮质纹状体途径重要的歌曲的变异性，这种影响可能部分归因于减少D1 R和DARPP-32蛋白水平。此外，歌唱鸟类的录音显示，FoxP 2敲低阻止了这一途径中与歌唱相关的活动的社会调节。这些发现表明，FoxP 2水平的降低会干扰多巴胺对声音变异性的调节，这可能会通过破坏强化学习机制来阻碍歌曲和语言的发展。
Mutations of the FOXP2 gene impair speech and language development in humans and shRNA-mediated suppression of the avian orthologue FoxP2 disrupts song learning in juvenile zebra finches. How diminished FoxP2 levels affect vocal control and alter the function of neural circuits important to learned vocalizations remains unclear. Here we show that FoxP2 knockdown in the songbird striatum disrupts developmental and social modulation of song variability. Recordings in anaesthetized birds show that FoxP2 knockdown interferes with D1R-dependent modulation of activity propagation in a corticostriatal pathway important to song variability, an effect that may be partly attributable to reduced D1R and DARPP-32 protein levels. Furthermore, recordings in singing birds reveal that FoxP2 knockdown prevents social modulation of singing-related activity in this pathway. These findings show that reduced FoxP2 levels interfere with the dopaminergic modulation of vocal variability, which may impede song and speech development by disrupting reinforcement learning mechanisms.
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影响因子：
9.2
作者：
Groszer, Matthias;Keays, David A.;Deacon, Robert M. J.;de Bono, Joseph P.;Prasad-Mulcare, Shweta;Gaub, Simone;Baum, Muriel G.;French, Catherine A.;Nicod, Jrme;Coventry, Julie A.;Enard, Wolfgang;Fray, Martin;Brown, Steve D. M.;Nolan, Patrick M.;Paeaebo, Svante;Channon, Keith M.;Costa, Rui M.;Eilers, Jens;Ehret, Guenter;Nicholas, J.;Rawlins, P.;Fisher, Simon E.
通讯作者：
Fisher, Simon E.
DOI：
10.1073/pnas.1216308110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Kojima, Satoshi;Kao, Mimi H.;Doupe, Allison J.
通讯作者：
Doupe, Allison J.
DOI：
10.1523/jneurosci.2250-08.2008
发表时间：
2008-12-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kao MH;Wright BD;Doupe AJ
通讯作者：
Doupe AJ
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.5
作者：
Kozhevnikov, Alexay A.;Fee, Michale S.
通讯作者：
Fee, Michale S.