Primary hypogammaglobulinaemia and arthritis.
Primary hypogammaglobulinaemia and arthritis.
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DOI：
10.1136/bmj.295.6591.174
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发表时间：
1987-07
期刊：
影响因子：
--
通讯作者：
T. Hansel;M. Haeney;R. Thompson
中科院分区：
文献类型：
--
作者：
T. Hansel;M. Haeney;R. Thompson
关节炎可能是原发性低丙种球蛋白血症的首发临床表现。在16年的281例免疫缺陷患者中，30例在就诊时患有关节炎。它在布鲁顿病（69例患者中的15例（22%））中比其他形式的免疫缺陷（212例患者中的15例（7%））更常见。非脓毒性关节炎比脓毒性关节炎更常见，特别是布鲁顿病中的单关节关节炎和常见变异性免疫缺陷中的少关节病。布鲁顿病诊断延迟的男孩很可能发展为关节炎并发的复发性感染。血清免疫球蛋白浓度的测量很容易区分免疫缺陷的条件，如斯蒂尔病，并指示随后的管理。
Arthritis may be the first clinical manifestation of primary hypogammaglobulinaemia. In 16 years of 281 patients who had immunodeficiency, 30 had arthritis at presentation. It was more common in Bruton's disease (15 (22%) of 69 patients) than in other forms of immunodeficiency (15 (7%) of 212 patients). Non-septic arthritis was more prevalent than septic arthritis, particularly monoarticular arthritis in Bruton's disease and pauciarticular disease in common variable immunodeficiency. Boys in whom a diagnosis of Bruton's disease was delayed were likely to develop recurrent infections complicated by arthritis. The measurement of serum immunoglobulin concentrations readily differentiates immunodeficiency from conditions such as Still's disease and dictates subsequent management.