Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 2)
Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 2)
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DOI：
10.1111/j.1741-4520.2009.00239.x
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发表时间：
2009-09-01
影响因子：
1.3
通讯作者：
Wise, L. David
中科院分区：
文献类型：
--
作者：
Makris, Susan L.;Solomon, Howard M.;Wise, L. David
本更新版（第2版）对普通实验室哺乳动物发育异常术语（第1版）的内容和组织进行了改进和增强，以提高其应用的灵活性，同时保持对结果描述的一致性。这些修订是有关组织在个别专家的建议下进行国际合作的结果，也是若干讲习班成果的结果。按照发育毒性研究中通常收集和记录数据的方式，术语仍按照外部、内脏和骨骼观察结果的大类组织成表格。表格的这种安排以及附录中提供的其他信息旨在促进实验室工作台水平的样本评价过程。当前术语表中仅涉及常用的实验室哺乳动物（即大鼠、小鼠、兔）。纳入发育毒性试验中使用的其他物种（如灵长类动物）被认为超出了本更新的范围。同样，根据本文件的重点是描述性术语而不是诊断或解释的总体原则，将结果分类为“畸形”或“变异”仍然没有得到解决。增加了骨骼术语以适应软骨发现。
This update (Version 2) of the Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 1) incorporates improvements and enhancements to both content and organization of the terminology to enable greater flexibility in its application, while maintaining a consistent approach to the description of findings. The revisions are the result of an international collaboration among interested organizations, advised by individual experts and the outcomes of several workshops. The terminology remains organized into tables under the broad categories of external, visceral, and skeletal observations, following the manner in which data are typically collected and recorded in developmental toxicity studies. This arrangement of the tables, as well as other information provided in appendices, is intended to facilitate the process of specimen evaluation at the laboratory bench level. Only the commonly used laboratory mammals (i.e. rats, mice, rabbits) are addressed in the current terminology tables. The inclusion of other species that are used in developmental toxicity testing, such as primates, is considered outside the scope of the present update. Similarly, categorization of findings as, for example, 'malformation' or 'variation' remains unaddressed, in accordance with the overall principle that the focus of this document is descriptive terminology and not diagnosis or interpretation. The skeletal terms have been augmented to accommodate cartilage findings.